Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
dc.contributor.author | Neal, Charles Richard | en_US |
dc.contributor.author | Mansour, Alfred | en_US |
dc.contributor.author | Reinscheid, Rainer | en_US |
dc.contributor.author | Nothacker, Hans-Peter | en_US |
dc.contributor.author | Civelli, Olivier | en_US |
dc.contributor.author | Watson, Stanley J. | en_US |
dc.date.accessioned | 2006-04-19T13:35:01Z | |
dc.date.available | 2006-04-19T13:35:01Z | |
dc.date.issued | 1999-04-19 | en_US |
dc.identifier.citation | Neal, Charles R.; Mansour, Alfred; Reinscheid, Rainer; Nothacker, Hans-Peter; Civelli, Olivier; Watson, Stanley J. (1999)."Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat." The Journal of Comparative Neurology 406(4): 503-547. <http://hdl.handle.net/2027.42/34452> | en_US |
dc.identifier.issn | 0021-9967 | en_US |
dc.identifier.issn | 1096-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34452 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10205026&dopt=citation | en_US |
dc.description.abstract | Orphanin FQ (OFQ) is the endogenous agonist of the opioid receptor-like receptor (ORL-1). It and its precursor, prepro-OFQ, exhibit structural features suggestive of the opioid peptides. A cDNA encoding the OFQ precursor sequence in the rat recently has been cloned, and the authors recently generated a polyclonal antibody directed against the OFQ peptide. In the present study, the authors used in situ hybridization and immunohistochemistry to examine the distribution of OFQ peptide and mRNA in the central nervous system of the adult rat. OFQ immunoreactivity and prepro-OFQ mRNA expression correlated virtually in all brain areas studied. In the forebrain, OFQ peptide and mRNA were prominent in the neocortex endopiriform nucleus, claustrum, lateral septum, ventral forebrain, hypothalamus, mammillary bodies, central and medial nuclei of the amygdala, hippocampal formation, paratenial and reticular nuclei of the thalamus, medial habenula, and zona incerta. No OFQ was observed in the pineal or pituitary glands. In the brainstem, OFQ was prominent in the ventral tegmental area, substantia nigra, nucleus of the posterior commissure, central gray, nucleus of Darkschewitsch, peripeduncular nucleus, interpeduncular nucleus, tegmental nuclei, locus coeruleus, raphe complex, lateral parabrachial nucleus, inferior olivary complex, vestibular nuclear complex, prepositus hypoglossus, solitary nucleus, nucleus ambiguous, caudal spinal trigeminal nucleus, and reticular formation. In the spinal cord, OFQ was observed throughout the dorsal and ventral horns. The wide distribution of this peptide provides support for its role in a multitude of functions, including not only nociception but also motor and balance control, special sensory processing, and various autonomic and physiologic processes. J. Comp. Neurol. 406:503–547, 1999. © 1999 Wiley-Liss, Inc. | en_US |
dc.format.extent | 2478163 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 ; Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 ; Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 ; Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 | en_US |
dc.contributor.affiliationother | Pharmaco Genesis Corporation, West Bloomfield, Michigan 48322 | en_US |
dc.contributor.affiliationother | University Hospital Eppendorf, Hamburg, Germany | en_US |
dc.contributor.affiliationother | Department of Pharmacology, College of Medicine, University of California-Irvine, Irvine, California 92697-4625 | en_US |
dc.contributor.affiliationother | Department of Pharmacology, College of Medicine, University of California-Irvine, Irvine, California 92697-4625 | en_US |
dc.identifier.pmid | 10205026 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34452/1/7_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1096-9861(19990419)406:4<503::AID-CNE7>3.0.CO;2-P | en_US |
dc.identifier.source | The Journal of Comparative Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.