Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with 125 I-[ 14 Tyr]-orphanin FQ binding
dc.contributor.author | Neal, Charles Richard | en_US |
dc.contributor.author | Mansour, Alfred | en_US |
dc.contributor.author | Reinscheid, Rainer | en_US |
dc.contributor.author | Nothacker, Hans-Peter | en_US |
dc.contributor.author | Civelli, Olivier | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.contributor.author | Watson, Stanley J. | en_US |
dc.date.accessioned | 2006-04-19T13:35:12Z | |
dc.date.available | 2006-04-19T13:35:12Z | |
dc.date.issued | 1999-10-04 | en_US |
dc.identifier.citation | Neal, Charles R.; Mansour, Alfred; Reinscheid, Rainer; Nothacker, Hans-Peter; Civelli, Olivier; Akil, Huda; Watson, Stanley J. (1999)."Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with 125 I-[ 14 Tyr]-orphanin FQ binding." The Journal of Comparative Neurology 412(4): 563-605. <http://hdl.handle.net/2027.42/34456> | en_US |
dc.identifier.issn | 0021-9967 | en_US |
dc.identifier.issn | 1096-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34456 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10464356&dopt=citation | en_US |
dc.description.abstract | The recently discovered neuropeptide orphanin FQ (OFQ), and its opioid receptor-like (ORL1) receptor, exhibit structural features suggestive of the μ, κ, and δ opioid systems. The anatomic distribution of OFQ immunoreactivity and mRNA expression has been reported recently. In the present analysis, we compare the distribution of orphanin receptor mRNA expression with that of orphanin FQ binding at the ORL1 receptor in the adult rat central nervous system (CNS). By using in vitro receptor autoradiography with 125 I-[ 14 Tyr]-OFQ as the radioligand, orphanin receptor binding was analyzed throughout the rat CNS. Orphanin binding sites were densest in several cortical regions, the anterior olfactory nucleus, lateral septum, ventral forebrain, several hypothalamic nuclei, hippocampal formation, basolateral and medial amygdala, central gray, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus, vestibular nuclear complex, and the spinal cord. By using in situ hybridization, cells expressing ORL1 mRNA were most numerous throughout multiple cortical regions, the anterior olfactory nucleus, lateral septum, endopiriform nucleus, ventral forebrain, multiple hypothalamic nuclei, nucleus of the lateral olfactory tract, medial amygdala, hippocampal formation, substantia nigra, ventral tegmental area, central gray, raphe complex, locus coeruleus, multiple brainstem motor nuclei, inferior olive, deep cerebellar nuclei, vestibular nuclear complex, nucleus of the solitary tract, reticular formation, dorsal root ganglia, and spinal cord. The diffuse distribution of ORL1 mRNA and binding supports an extensive role for orphanin FQ in a multitude of CNS functions, including motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression, and autonomic control of physiologic processes. J. Comp. Neurol. 412:563–605, 1999. © 1999 Wiley-Liss, Inc. | en_US |
dc.format.extent | 2216384 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with 125 I-[ 14 Tyr]-orphanin FQ binding | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 ; Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 ; Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 ; Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0720 | en_US |
dc.contributor.affiliationother | Pharmaco Genesis Corporation, West Bloomfield, Michigan 48322 | en_US |
dc.contributor.affiliationother | University Hospital Eppendorf, D-20246 Hamburg, Germany | en_US |
dc.contributor.affiliationother | Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California 92697-4625 | en_US |
dc.contributor.affiliationother | Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California 92697-4625 | en_US |
dc.identifier.pmid | 10464356 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34456/1/2_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1096-9861(19991004)412:4<563::AID-CNE2>3.0.CO;2-Z | en_US |
dc.identifier.source | The Journal of Comparative Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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