Evaluation of the hairless rat as a model for in vivo percutaneous absorption
dc.contributor.author | Lauer, Andrea C. | en_US |
dc.contributor.author | Elder, James T. | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.date.accessioned | 2006-04-19T13:36:43Z | |
dc.date.available | 2006-04-19T13:36:43Z | |
dc.date.issued | 1997-01 | en_US |
dc.identifier.citation | Lauer, Andrea C.; Elder, James T.; Weiner, Norman D. (1997)."Evaluation of the hairless rat as a model for in vivo percutaneous absorption." Journal of Pharmaceutical Sciences 86(1): 13-18. <http://hdl.handle.net/2027.42/34489> | en_US |
dc.identifier.issn | 0022-3549 | en_US |
dc.identifier.issn | 1520-6017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34489 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9002453&dopt=citation | en_US |
dc.description.abstract | Percutaneous absorption of topically applied mannitol and progesterone was compared in vivo with the hairless and hairy rat. Urinary excretion and skin concentration profiles after topical application of mannitol demonstrated that hairless rat skin was a “leakier” barrier to percutaneous absorption of polar compounds than was hairy rat skin, independent of formulation. Liposomal, but not aqueous mannitol was retained in hairy rat skin (> 0.5% after 12 h), whereas only negligible amounts were retained in hairless rat skin, regardless of formulation. Progesterone absorption from hydroalcohol and liposomal formulations into hairless rat skin was about five times greater than that in hairy rat skin. Skin delipidization by acetone resulted in a dramatic reduction in the cutaneous barrier to systemic mannitol absorption, which was much more pronounced in hairy than in hairless rat skin. Histological findings of patulous cysts and enlarged, highly vascularized sebaceous glands in the hairless rat suggested that these structures may enhance polar pathways and provide a lipophilic reservoir relative to the fully developed hair follicles of the hairy rat. Collectively, the results document percutaneous absorption differences as a function of animal model, and also suggest that follicular structures make a major contribution to passive percutaneous absorption. | en_US |
dc.format.extent | 193513 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry | en_US |
dc.title | Evaluation of the hairless rat as a model for in vivo percutaneous absorption | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, MI 48109. | en_US |
dc.contributor.affiliationum | Department of Dermatology and Radiation Oncology (Cancer Biology), University of Michigan, School of Medicine, Ann Arbor, MI 48109. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, MI 48109. ; College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, MI 48109. | en_US |
dc.identifier.pmid | 9002453 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34489/1/2_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(ISSN)1520-6017 | en_US |
dc.identifier.source | Journal of Pharmaceutical Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.