Sustained and controlled release of daunomycin from cross-linked poly(aldehyde guluronate) hydrogels
dc.contributor.author | Bouhadir, Kamal H. | en_US |
dc.contributor.author | Kruger, Geneveive M. | en_US |
dc.contributor.author | Lee, Kuen-Yong | en_US |
dc.contributor.author | Mooney, David J. | en_US |
dc.date.accessioned | 2006-04-19T13:37:18Z | |
dc.date.available | 2006-04-19T13:37:18Z | |
dc.date.issued | 2000-07 | en_US |
dc.identifier.citation | Bouhadir, Kamal H.; Kruger, Geneveive M.; Lee, Kuen Yong; Mooney, David J. (2000)."Sustained and controlled release of daunomycin from cross-linked poly(aldehyde guluronate) hydrogels." Journal of Pharmaceutical Sciences 89(7): 910-919. <http://hdl.handle.net/2027.42/34502> | en_US |
dc.identifier.issn | 0022-3549 | en_US |
dc.identifier.issn | 1520-6017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34502 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10861592&dopt=citation | en_US |
dc.description.abstract | We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly(aldehyde guluronate). Adipic dihydrazide was used to incorporate the drug into the polymer backbone and cross-link the polymer to form hydrogels. Daunomycin can be released from the hydrogel after the hydrolysis of the covalent linkage between the drug and the polymer. A wide range of release profiles of daunomycin (e.g., from 2 days to 6 weeks) has been achieved using these materials, and the biological activity of the released daunomycin was maintained. © 2000 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 89: 910–919, 2000 | en_US |
dc.format.extent | 257605 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry | en_US |
dc.title | Sustained and controlled release of daunomycin from cross-linked poly(aldehyde guluronate) hydrogels | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Bldg., 2300 Hayward Street, Ann Arbor, Michigan 48109-2136 ; Department of Biological & Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineeering, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Bldg., 2300 Hayward Street, Ann Arbor, Michigan 48109-2136 ; Department of Biological & Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Bldg., 2300 Hayward Street, Ann Arbor, Michigan 48109-2136 ; Department of Biomedical Engineeering, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Biological & Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Bldg., 2300 Hayward Street, Ann Arbor, Michigan 48109-2136; (Telephone: 734-763-4816; Fax: 734-763-0459) | en_US |
dc.identifier.pmid | 10861592 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34502/1/8_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/1520-6017(200007)89:7<910::AID-JPS8>3.0.CO;2-# | en_US |
dc.identifier.source | Journal of Pharmaceutical Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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