Altered regional brain glucose metabolism in Duchenne muscular dystrophy: A pet study
dc.contributor.author | Lee, Joon Soo | en_US |
dc.contributor.author | Pfund, Zoltán | en_US |
dc.contributor.author | Juhász, Csaba | en_US |
dc.contributor.author | Behen, Michael E. | en_US |
dc.contributor.author | Muzik, Otto | en_US |
dc.contributor.author | Chugani, Diane C. | en_US |
dc.contributor.author | Nigro, Michael A. | en_US |
dc.contributor.author | Chugani, Harry T. | en_US |
dc.date.accessioned | 2006-04-19T13:43:21Z | |
dc.date.available | 2006-04-19T13:43:21Z | |
dc.date.issued | 2002-10 | en_US |
dc.identifier.citation | Lee, Joon Soo; Pfund, ZoltÁn; JuhÁsz, Csaba; Behen, Michael E.; Muzik, Otto; Chugani, Diane C.; Nigro, Michael A.; Chugani, Harry T. (2002)."Altered regional brain glucose metabolism in Duchenne muscular dystrophy: A pet study." Muscle & Nerve 26(4): 506-512. <http://hdl.handle.net/2027.42/34635> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34635 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12362416&dopt=citation | en_US |
dc.description.abstract | The basis for cognitive impairment in Duchenne muscular dystrophy (DMD) is not well understood but may be related to abnormal expression of dystrophin in brain. The aim of this study was to determine whether regional brain glucose metabolism is altered in children with DMD and whether such metabolic disturbances are localized to regions shown to be normally rich in dystrophin expression. Ten boys (mean age, 11.8 years) with DMD and 17 normal adults as a control group (mean age, 27.6 years) underwent 2-deoxy-2[ 18 F]fluoro-D-glucose positron emission tomography (PET) and neuropsychological evaluation. The PET data were analyzed by statistical parametric mapping (SPM). The SPM analysis showed five clusters of decreased glucose metabolism in children with DMD, including the medial temporal structures and cerebellum bilaterally and the sensorimotor and lateral temporal cortex on the right side. At the voxel level, significant glucose hypometabolism was found in the right postcentral and middle temporal gyri, uncus, and VIIIB cerebellar lobule, as well as in the left hippocampal gyrus and cerebellar lobule. The neuropsychological profile of the DMD group revealed borderline nonverbal intellectual functioning, impaired manual dexterity bilaterally, borderline cognitive functioning, and internalizing behavioral difficulties. Our findings demonstrate region-specific hypometabolism, as well as cognitive and behavioral deficits in DMD children. As the regions showing hypometabolism on PET include those normally rich in dystrophin expression, it will be important to determine whether the hypometabolic regions also show cytoarchitectural abnormalities related to the lack of dystrophin. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26:506-512, 2002 | en_US |
dc.format.extent | 892225 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Altered regional brain glucose metabolism in Duchenne muscular dystrophy: A pet study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA ; Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA ; Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA ; Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA ; Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA ; Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA ; Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA | en_US |
dc.identifier.pmid | 12362416 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34635/1/10238_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mus.10238 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.