Number of contractions to maintain mass and force of a denervated rat muscle
dc.contributor.author | Dow, Douglas E. | en_US |
dc.contributor.author | Cederna, Paul S. | en_US |
dc.contributor.author | Hassett, Cheryl A. | en_US |
dc.contributor.author | Kostrominova, Tatiana Y. | en_US |
dc.contributor.author | Faulkner, John A. | en_US |
dc.contributor.author | Dennis, Robert G. | en_US |
dc.date.accessioned | 2006-04-19T13:43:30Z | |
dc.date.available | 2006-04-19T13:43:30Z | |
dc.date.issued | 2004-07 | en_US |
dc.identifier.citation | Dow, Douglas E.; Cederna, Paul S.; Hassett, Cheryl A.; Kostrominova, Tatiana Y.; Faulkner, John A.; Dennis, Robert G. (2004)."Number of contractions to maintain mass and force of a denervated rat muscle." Muscle & Nerve 30(1): 77-86. <http://hdl.handle.net/2027.42/34638> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34638 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15221882&dopt=citation | en_US |
dc.description.abstract | Within 5 weeks, denervated extensor digitorum longus (EDL) muscles of rats lose 66% of mass, 91% of force, and 76% of fiber cross-sectional area (CSA). We previously determined the parameters of electrical stimulation for denervated rat EDL muscles to generate tetanic contractions sufficient to maintain mass and force close to control values. Using these parameters, we tested the hypothesis that a range exists for number of contractions per day, below and above which values for mass, maximum force, and fiber CSA are lower than values for innervated control muscles. For 5 weeks, denervated EDL muscles were stimulated to generate between 25 and 5000 contractions daily with contractions separated by constant intervals of rest, repeated 24 h per day. Force was not maintained with fewer than 200 or more than 800 contractions daily, whereas mass and fiber CSA were not maintained with fewer than 50 contractions daily. Protocols of stimulation that maintain muscle mass and force during prolonged periods of denervation may minimize problems clinically associated with denervation atrophy. Muscle Nerve 30: 77–86, 2004 | en_US |
dc.format.extent | 293325 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Number of contractions to maintain mass and force of a denervated rat muscle | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA ; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA ; Department of Mechanical Engineering, University of Michigan, 2350 Hayward, Room 3116, Ann Arbor, Michigan 48109-2125, USA ; Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 15221882 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34638/1/20054_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mus.20054 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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