Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample
dc.contributor.author | Skol, Andrew D. | en_US |
dc.contributor.author | Young, K. A. | en_US |
dc.contributor.author | Tsuang, D. W. | en_US |
dc.contributor.author | Faraone, S. V. | en_US |
dc.contributor.author | Haverstock, S. L. | en_US |
dc.contributor.author | Bingham, S. | en_US |
dc.contributor.author | Prabhudesai, S. | en_US |
dc.contributor.author | Mena, F. | en_US |
dc.contributor.author | Menon, A. S. | en_US |
dc.contributor.author | Yu, Chang-En | en_US |
dc.contributor.author | Rundell, Paul | en_US |
dc.contributor.author | Pepple, J. | en_US |
dc.contributor.author | Sauter, F. | en_US |
dc.contributor.author | Baldwin, C. | en_US |
dc.contributor.author | Weiss, D. | en_US |
dc.contributor.author | Collins, J. | en_US |
dc.contributor.author | Keith, T. | en_US |
dc.contributor.author | Boehnke, Michael | en_US |
dc.contributor.author | Schellenberg, Gerard D. | en_US |
dc.contributor.author | Tsuang, M. T. | en_US |
dc.date.accessioned | 2006-04-19T13:44:51Z | |
dc.date.available | 2006-04-19T13:44:51Z | |
dc.date.issued | 2003-04-01 | en_US |
dc.identifier.citation | Skol, A.D.; Young, K.A.; Tsuang, D.W.; Faraone, S.V.; Haverstock, S.L.; Bingham, S.; Prabhudesai, S.; Mena, F.; Menon, A.S.; Yu, Chang-En; Rundell, Paul; Pepple, J.; Sauter, F.; Baldwin, C.; Weiss, D.; Collins, J.; Keith, T.; Boehnke, M.; Schellenberg, G.D.; Tsuang, M.T. (2003)."Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample." American Journal of Medical Genetics 118B(1): 8-15. <http://hdl.handle.net/2027.42/34667> | en_US |
dc.identifier.issn | 0148-7299 | en_US |
dc.identifier.issn | 1096-8628 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34667 | |
dc.description.abstract | Wei and Hemmings [2000: Nat Genet 25:376–377], using 80 British parent–offspring trios, identified a number of NOTCH4 variants and haplotypes that showed statistically significant evidence of association to schizophrenia. Specifically, the 10 repeat allele of a (CTG) n marker and the 8 repeat allele of a (TAA) n marker demonstrated excess transmission to affected individuals; SNP2 1 and haplotypes SNP2-(CTG) n and SNP1 2 -SNP2-(CTG) n also showed significant associations. In an attempt to replicate these findings, we tested for linkage and association between the same five markers used by Wei and Hemmings in 166 families collected from a multi-center study conducted by the Department of Veterans Affairs (DVA) Cooperative Study Program (CSP). The families include 392 affected subjects (schizophrenia or schizoaffective disorder, depressed) and 216 affected sibling pairs. The families represent a mix of European Americans (n = 62, 37%), African Americans (n = 60, 36%), and racially mixed or other races (n = 44, 27%). We identified moderate evidence for linkage in the pooled race sample (LOD = 1.25) and found excess transmission of the 8 ( P = 0.06) and 13 ( P = 0.04) repeat alleles of the (TAA) n marker to African American schizophrenic subjects. The 8 and 13 repeat alleles were previously identified to be positively associated with schizophrenia by Wei and Hemmings [2000: Nat Genet 25:376–377] and Sklar et al. [2001: Nat Genet 28:126–128], respectively. © 2003 Wiley-Liss, Inc. | en_US |
dc.format.extent | 93380 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center Waco, Texas | en_US |
dc.contributor.affiliationother | Veterans Affairs Puget Sound Health Care System, Mental Illness, Research, Education, and Clinical Center, and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington | en_US |
dc.contributor.affiliationother | Brockton West Roxbury Veterans Affairs Medical Center, Brockton, Massachusetts, and Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center ; Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, Massachusetts ; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Augusta, Georgia | en_US |
dc.contributor.affiliationother | Cooperative Studies Program Coordinating Center, Veterans Affairs Medical Center, Perry Point, Maryland | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Danville, Illinois | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Tuskegee, Alabama | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Perry Point, Maryland | en_US |
dc.contributor.affiliationother | Veterans Affairs Puget Sound Health Care System, Geriatric Research, Education, and Clinical Center, and Departments of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington | en_US |
dc.contributor.affiliationother | Veterans Affairs Puget Sound Health Care System, Geriatric Research, Education, and Clinical Center, and Departments of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington | en_US |
dc.contributor.affiliationother | Brockton West Roxbury Veterans Affairs Medical Center, Brockton, Massachusetts, and Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center ; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, New Orleans, Louisiana | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Northport, New York | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Augusta, Georgia | en_US |
dc.contributor.affiliationother | Veterans Affairs Medical Center, Augusta, Georgia | en_US |
dc.contributor.affiliationother | Veterans Affairs Puget Sound Health Care System, Geriatric Research, Education, and Clinical Center, and Departments of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington ; VAPSHCS, 182 GRECC, 1660 S. Columbian Way, Seattle, WA 98108; 206-764-2701. | en_US |
dc.contributor.affiliationother | Brockton West Roxbury Veterans Affairs Medical Center, Brockton, Massachusetts, and Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center ; Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, Massachusetts ; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34667/1/10055_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ajmg.b.10055 | en_US |
dc.identifier.source | American Journal of Medical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.