Heart development in Drosophila and vertebrates: Conservation of molecular mechanisms
dc.contributor.author | Bodmer, Rolf | en_US |
dc.contributor.author | Venkatesh, Tyamagondlu V. | en_US |
dc.date.accessioned | 2006-04-19T13:45:40Z | |
dc.date.available | 2006-04-19T13:45:40Z | |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Bodmer, Rolf; Venkatesh, Tyamagondlu V. (1998)."Heart development in Drosophila and vertebrates: Conservation of molecular mechanisms." Developmental Genetics 22(3): 181-186. <http://hdl.handle.net/2027.42/34685> | en_US |
dc.identifier.issn | 0192-253X | en_US |
dc.identifier.issn | 1520-6408 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34685 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9621426&dopt=citation | en_US |
dc.description.abstract | Vertebrate and insect ( Drosophila ) hearts look and function quite differently from each other. Nevertheless, during embryogenesis their mesodermal origin and initial assembly into a linear heart tube are comparable in many respects. In the past few years, numerous gene functions have been identified that are utilized by both vertebrates and Drosophila for the specification and differentiation of the heart progenitor cells. These studies have begun with the discovery of the homeobox gene tinman in Drosophila and its vertebrate counterparts. By now, there is also evidence that MEF2 transcription factors and TGF-β signaling have cardiogenic functions in both these systems. Perhaps in a few years, the GATA and HAND transcription factors and Wnt signaling, which currently only have a demonstrated cardiogenic function in one of the systems, may also be part of this group. One of the pressing but still wide open questions is if the spectrum of targets for these transcription factors and signaling pathways is also conserved. Dev. Genet. 22:181–186, 1998. © 1998 Wiley-Liss, Inc. | en_US |
dc.format.extent | 61233 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Heart development in Drosophila and vertebrates: Conservation of molecular mechanisms | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, Michigan ; (until July 1998) c/o Dr. C. Goridis, IBDM, Campus de Luminy, case 907, F-13288 Marseille, Cedex 9, France. E-mail: bodmer@ibdm.univ-mrs.fr After July 1998: Dr. Rolf Bodmer, Dept. of Biology, University of Michigan, 830 N. University, Ann Arbor, MI 48109-1048. E-mail: rolf@umich.edu | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 9621426 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34685/1/1_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1520-6408(1998)22:3<181::AID-DVG1>3.0.CO;2-2 | en_US |
dc.identifier.source | Developmental Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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