Dual role for the zeste-white3/shaggy -encoded kinase in mesoderm and heart development of Drosophila
dc.contributor.author | Park, Maiyon | en_US |
dc.contributor.author | Venkatesh, Tyamagondlu V. | en_US |
dc.contributor.author | Bodmer, Rolf | en_US |
dc.date.accessioned | 2006-04-19T13:45:43Z | |
dc.date.available | 2006-04-19T13:45:43Z | |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Park, Maiyon; Venkatesh, Tyamagondlu V.; Bodmer, Rolf (1998)."Dual role for the zeste-white3/shaggy -encoded kinase in mesoderm and heart development of Drosophila ." Developmental Genetics 22(3): 201-211. <http://hdl.handle.net/2027.42/34686> | en_US |
dc.identifier.issn | 0192-253X | en_US |
dc.identifier.issn | 1520-6408 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34686 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9621428&dopt=citation | en_US |
dc.description.abstract | A Drosophila homolog of the serine/threonine kinase GSK-3β, encoded by the zest-white3/shaggy gene ( zw3 ), has been implicated as a maternally provided antagonist of zygotic signaling by the secreted segmentation gene wingless ( wg ). The wg signal apparently causes a spatially localized inhibition of the ubiquitous repressor function of zw3. This double negative mechanism of signal transduction has been shown to mediate the patterning function of Wg in a number of developmental processes. Although wg is absolutely required for specifying the heart progenitors within the mesoderm of Drosophila, the role of zw3 in this process has been unclear. Here, we present evidence that zw3 has a dual role in mesoderm development: (1) zw3 acts as an antagonist in cardiogenic wg signal transduction, and (2) zw3 also seems to be required to promote positively the formation of a larger mesodermal region, the tinman - and dpp -dependent “dorsal mesoderm,” which is a prerequisite not only for cardiogenesis, but also for visceral mesoderm formation. We also demonstrate that a recently identified proximal component of the wg cascade, which is a transcription factor encoded by pangolin/dTCF ( dTCF ), also seems to mediate wg -dependent cardiogenesis. Further, we present evidence that Notch ( N ), which opposes wg signaling in other situations, is unlikely to be directly involved in the cardiogenic wg pathway, but seems to have multiple other myogenic functions, one of which is to inhibit mesoderm differentiation altogether, when overexpressed as a constitutively active form. Dev. Genet. 22:201–211, 1998. © 1998 Wiley-Liss, Inc. | en_US |
dc.format.extent | 904220 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Dual role for the zeste-white3/shaggy -encoded kinase in mesoderm and heart development of Drosophila | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, Michigan ; who is now at IBDM, (until July 1998), Campus de Luminy, case 907, F-13288 Marseille, France.-mrs.fr After July 1998: Dr. Rolf Bodmer, Dept. of Biology, University of Michigan, 830 N. University, Ann Arbor, MI 48109–1048. E-mail:rolf@umich.edu | en_US |
dc.identifier.pmid | 9621428 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34686/1/3_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1520-6408(1998)22:3<201::AID-DVG3>3.0.CO;2-A | en_US |
dc.identifier.source | Developmental Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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