Protection from half-mustard-gas-induced acute lung injury in the rat
dc.contributor.author | McClintock, Shannon D. | en_US |
dc.contributor.author | Till, Gerd O. | en_US |
dc.contributor.author | Smith, Milton G. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.date.accessioned | 2006-04-19T13:46:32Z | |
dc.date.available | 2006-04-19T13:46:32Z | |
dc.date.issued | 2002-07 | en_US |
dc.identifier.citation | McClintock, Shannon D.; Till, Gerd O.; Smith, Milton G.; Ward, Peter A. (2002)."Protection from half-mustard-gas-induced acute lung injury in the rat." Journal of Applied Toxicology 22(4): 257-262. <http://hdl.handle.net/2027.42/34704> | en_US |
dc.identifier.issn | 0260-437X | en_US |
dc.identifier.issn | 1099-1263 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34704 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12210543&dopt=citation | en_US |
dc.description.abstract | The chemical warfare agent analog, 2-chloroethyl ethyl sulfide, known as ‘half-mustard gas’ (HMG), is less toxic and less of an environmental hazard than the full molecule and has been shown to produce an acute lung injury in rats when instilled via intrapulmonary injection. This injury is characterized by massive, localized hemorrhage and edema into the alveolar compartment and can be quantitated by measuring extravasation of 125 I-bovine serum albumin into the extravascular compartment. Employing this rat model of HMG-induced lung injury, we observed significant attenuation of the pulmonary injury when experimental animals were complement or neutrophil depleted prior to HMG challenge. Significant protection also was provided by the use of antioxidants such as catalase, dimethyl sulfoxide, dimethyl thiourea, resveratrol and N -acetyl- L -cysteine (NAC). The last compound showed protection from lung injury as high as 70% and was still effective even when given up to 90 min after exposure of the lungs to HMG. These data suggest that acute lung injury caused by exposure to HMG may be related partially to complement mediated pathways and the generation by neutrophils of toxic oxygen species The data indicate that NAC is an effective antidote against HMG-induced acute lung injury in the rat. Copyright © 2002 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 122237 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Occupational Health and Environmental Toxicology | en_US |
dc.title | Protection from half-mustard-gas-induced acute lung injury in the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA ; University of Michigan Medical School, Department of Pathology, 1301 Catherine Street, Box 0602, Ann Arbor, MI 48109-0602, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA | en_US |
dc.contributor.affiliationother | Amaox Ltd, Silver Springs, MD, USA | en_US |
dc.identifier.pmid | 12210543 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34704/1/856_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jat.856 | en_US |
dc.identifier.source | Journal of Applied Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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