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Mini-microabscess syndrome in liver transplant recipients

dc.contributor.authorMacdonald, Graeme A.en_US
dc.contributor.authorGreenson, Joel K.en_US
dc.contributor.authorDel Buono, Elizabeth A.en_US
dc.contributor.authorGrady, W. M.en_US
dc.contributor.authorMerion, Robert M.en_US
dc.contributor.authorFrank, Thomas S.en_US
dc.contributor.authorLucey, Michael R.en_US
dc.contributor.authorAppelman, Henry D.en_US
dc.date.accessioned2006-04-19T13:49:30Z
dc.date.available2006-04-19T13:49:30Z
dc.date.issued1997-07en_US
dc.identifier.citationMacDonald, G A; Greenson, J K; DelBuono, E A; Grady, W M; Merion, R M; Frank, T S; Lucey, M R; Appelman, H D (1997)."Mini-microabscess syndrome in liver transplant recipients." Hepatology 26(1): 192-197. <http://hdl.handle.net/2027.42/34768>en_US
dc.identifier.issn0270-9139en_US
dc.identifier.issn1527-3350en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/34768
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9214469&dopt=citationen_US
dc.description.abstractCytomegalovirus (CMV) is a significant cause of morbidity in immunosuppressed patients. It is characterized in the liver by parenchymal microabscesses, usually containing CMV-infected cells. However, not all hepatic microabscesses are due to CMV infection. In 1992, we described “mini” microabscess (MMA) syndrome, a distinct clinical syndrome that occurs in transplanted livers. This report analyzes the clinical and laboratory features of 57 cases of MMA syndrome occurring in 52 patients and compares these with 19 biopsy-proven cases of CMV infection. The diagnosis of MMA syndrome can only be made histologically. The microabscesses are smaller and more numerous than in CMV infection, and there are no viral inclusions present. CMV DNA could not be detected in liver biopsy specimens with MMAs by using “nested” polymerase chain reaction (PCR), indicating that MMA syndrome is not caused by CMV infection. The pattern of liver enzyme and bilirubin elevation is predominantly hepatocellular, with transaminase levels elevated, on average, six to eight times the upper limit of normal. The clinical features of MMA syndrome are that it predominantly affects female (40 of 52 patients) orthotopic liver transplant (OLT) recipients of all ages (range, 11 months to 66.9 years). MMA syndrome is unrelated to the indication for initial OLT and tends to occur later after transplantation than CMV infection (median, 91 days post-OLT vs. 32 days for CMV hepatitis). Although the etiology of MMA syndrome is not clear, it does not appear to adversely affect graft or patient survival.en_US
dc.format.extent448288 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherHepatologyen_US
dc.titleMini-microabscess syndrome in liver transplant recipientsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.identifier.pmid9214469en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/34768/1/510260125_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/hep.510260125en_US
dc.identifier.sourceHepatologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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