Treatment of Wilson's disease with zinc. XVII: Treatment during pregnancy
dc.contributor.author | Brewer, George J. | en_US |
dc.contributor.author | Johnson, Virginia D. | en_US |
dc.contributor.author | Dick, Robert D. | en_US |
dc.contributor.author | Hedera, Peter | en_US |
dc.contributor.author | Fink, John K. | en_US |
dc.contributor.author | Kluin, Karen J. | en_US |
dc.date.accessioned | 2006-04-19T13:49:52Z | |
dc.date.available | 2006-04-19T13:49:52Z | |
dc.date.issued | 2000-02 | en_US |
dc.identifier.citation | Brewer, George J.; Johnson, Virginia D.; Dick, Robert D.; Hedera, Peter; Fink, John K.; Kluin, Karen J. (2000)."Treatment of Wilson's disease with zinc. XVII: Treatment during pregnancy." Hepatology 31(2): 364-370. <http://hdl.handle.net/2027.42/34776> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34776 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10655259&dopt=citation | en_US |
dc.description.abstract | Therapy of Wilson's disease continues to evolve. In 1997, zinc acetate was added to the list of drugs approved by the Food and Drug Administration, which includes penicillamine and trientine. The mechanism of zinc's anticopper action is unique. It induces intestinal cell metallothionein, which binds copper and prevents its transfer into blood. As intestinal cells die and slough, the contained copper is eliminated in the stool. Thus, zinc prevents the intestinal absorption of copper. It is universally agreed that pregnant Wilson's disease patients should remain on anticopper therapy during pregnancy. There are numerous reports of such patients stopping penicillamine therapy to protect their fetus from teratogenicity, only to undergo serious deterioration and even death from renewed copper toxicity. Penicillamine and trientine have teratogenic effects in animals, and penicillamine has known teratogenic effects in humans. In this report we discuss the results of 26 pregnancies in 19 women who were on zinc therapy throughout their pregnancy. The evidence is good that zinc protects the health of the mother during pregnancy. Fetal outcomes were generally quite good, although one baby had a surgically correctable heart defect and one had microcephaly.(Hepatology 2000;31:364-370.) | en_US |
dc.format.extent | 76976 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Treatment of Wilson's disease with zinc. XVII: Treatment during pregnancy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI ; The University of Michigan Medical School, Department of Human Genetics, 4708 Medical Science II, Ann Arbor, Michigan 48109-0618. fax: 734-615-2048 | en_US |
dc.contributor.affiliationum | Department of Human Genetics Division of Speech Pathology, and Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Human Genetics Division of Speech Pathology, and Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology Division of Speech Pathology, and Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology Division of Speech Pathology, and Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, Division of Speech Pathology, and Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.identifier.pmid | 10655259 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34776/1/510310216_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.510310216 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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