Hepatitis B e antigen–negative chronic hepatitis b in Hong Kong
dc.contributor.author | Chan, Henry L. Y. | en_US |
dc.contributor.author | Leung, Nancy W. Y. | en_US |
dc.contributor.author | Hussain, Munira T. | en_US |
dc.contributor.author | Wong, May L. | en_US |
dc.contributor.author | Lok, Anna Suk-Fong | en_US |
dc.date.accessioned | 2006-04-19T13:49:58Z | |
dc.date.available | 2006-04-19T13:49:58Z | |
dc.date.issued | 2000-03 | en_US |
dc.identifier.citation | Chan, Henry L. Y.; Leung, Nancy W. Y.; Hussain, Munira; Wong, May L.; Lok, Anna S. F. (2000)."Hepatitis B e antigen–negative chronic hepatitis b in Hong Kong." Hepatology 31(3): 763-768. <http://hdl.handle.net/2027.42/34778> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34778 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10706570&dopt=citation | en_US |
dc.description.abstract | Hepatitis B e antigen–negative chronic hepatitis B (e−CHB) has been reported in Asia but its prevalence and clinical significance have not been determined. The aims of this study were to determine the prevalence of e−CHB in Hong Kong and the frequency of precore and core promoter mutations in these patients. A cross-sectional study was performed in 350 consecutive Chinese patients (230 men and 120 women; mean age ±SD, 42 ± 13 years) with chronic hepatitis B virus infection. A total of 243 (69%) patients were hepatitis B e antigen (HBeAg)-negative of whom 15% had clinical cirrhosis. In the remaining 85% of patients, 63% had normal and 22% had elevated transaminases. Serum hepatitis B virus (HBV) DNA was detectable using branched DNA assay in 46% of HBeAg-negative patients with clinical cirrhosis/elevated transaminases. Forty-five percent of the patients with e−CHB had the precore stop codon mutation, and an additional 41% had core promoter changes. There was no correlation between the presence of precore/core promoter mutations and liver disease or HBV-DNA levels. Overall, 17% of HBeAg-negative patients were viremic and had evidence of chronic liver disease (e−CHB) with mean HBV-DNA levels comparable with that in HBeAg-positive patients. In summary, we found that e−CHB may be present in up to 17% of HBeAg-negative patients seen in a tertiary referral center in Hong Kong. e−CHB may be a heterogenous condition and is not invariably associated with the precore HBV mutant. Population studies are needed to determine the true prevalence of e−CHB in Asia and to assess its natural course and response to treatment. | en_US |
dc.format.extent | 82691 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Hepatitis B e antigen–negative chronic hepatitis b in Hong Kong | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan and VA Medical Center, Ann Arbor, MI ; Division of Gastroenterology and Hepatology, Prince of Wales Hospital, Hong Kong SAR, China | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan and VA Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan and VA Medical Center, Ann Arbor, MI ; Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109. fax: 734-936-7392 | en_US |
dc.contributor.affiliationother | Division of Gastroenterology and Hepatology, Prince of Wales Hospital, Hong Kong SAR, China | en_US |
dc.contributor.affiliationother | Division of Gastroenterology and Hepatology, Prince of Wales Hospital, Hong Kong SAR, China | en_US |
dc.identifier.pmid | 10706570 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34778/1/510310330_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.510310330 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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