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Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptors
dc.contributor.authorMatsunobu, Takeshien_US
dc.contributor.authorChung, Jong Wooen_US
dc.contributor.authorSchacht, Jochenen_US
dc.date.accessioned2006-04-19T13:55:03Z
dc.date.available2006-04-19T13:55:03Z
dc.date.issued2001-02-01en_US
dc.identifier.citationMatsunobu, Takeshi; Chung, Jong Woo; Schacht, Jochen (2001)."Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptors." Journal of Neuroscience Research 63(3): 252-256. <http://hdl.handle.net/2027.42/34867>en_US
dc.identifier.issn0360-4012en_US
dc.identifier.issn1097-4547en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/34867
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11170174&dopt=citationen_US
dc.description.abstractThe medial efferent system innervates outer hair cells in the organ of Corti. Neurotransmission at this synapse is mediated by acetylcholine (ACh) acting on nicotinic ACh receptors containing the Α9 subunit. In addition to the sensory cells, the supporting cells of the mammalian cochlea also receive efferent innervation but the neurotransmitter(s) at these synapses are not known. We show slow transient increases of intracellular calcium evoked by ACh in isolated Deiters' cells of the guinea pig cochlea. The antagonists atropine, d-tubocurarine and strychnine blocked the ACh-effect. Nicotine was an ineffective agonist. The pharmacologic profile and the kinetics of the calcium response suggest an Α9-like ACh receptor on Deiters' cells similar but not identical to that on the outer hair cells. J. Neurosci. Res. 63:252–256, 2001. © 2001 Wiley-Liss, Inc.en_US
dc.format.extent93035 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleAcetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptorsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan ; Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japanen_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan ; Department of Otolaryngology, Asan Medical Center, University of Ulsan, Seoul, Koreaen_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan ; Kresge Hearing Research Institute, 1301 East Ann Street, Ann Arbor, MI 48109-0506en_US
dc.identifier.pmid11170174en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/34867/1/1018_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/1097-4547(20010201)63:3<252::AID-JNR1018>3.0.CO;2-0en_US
dc.identifier.sourceJournal of Neuroscience Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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