Calcineurin activation contributes to noise-induced hearing loss
dc.contributor.author | Minami, Shujiro B. | en_US |
dc.contributor.author | Yamashita, Daisuke | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.contributor.author | Miller, Josef M. | en_US |
dc.date.accessioned | 2006-04-19T13:55:09Z | |
dc.date.available | 2006-04-19T13:55:09Z | |
dc.date.issued | 2004-11-01 | en_US |
dc.identifier.citation | Minami, Shujiro B.; Yamashita, Daisuke; Schacht, Jochen; Miller, Josef M. (2004)."Calcineurin activation contributes to noise-induced hearing loss." Journal of Neuroscience Research 78(3): 383-392. <http://hdl.handle.net/2027.42/34869> | en_US |
dc.identifier.issn | 0360-4012 | en_US |
dc.identifier.issn | 1097-4547 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34869 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15389832&dopt=citation | en_US |
dc.description.abstract | Acoustic overstimulation increases Ca 2+ concentration in auditory hair cells. Because calcineurin is known to activate cell death pathways and is controlled by Ca 2+ and calmodulin, this study assessed the role of calcineurin in auditory hair cell death in guinea pigs after intense noise exposure. Immediately after noise exposure (4-kHz octave band, 120 dB, for 5 hr), a population of hair cells exhibited calcineurin immunoreactivity at the cuticular plate, with a decreasing number of positive-stained cells on Days 1–3. By Day 7, the levels of calcineurin immunoreactivity had diminished to near control, non-noise exposed values, concomitant with an increasing loss of hair cells. Staining of hair cell nuclei with propidium iodide (PI), restricted to calcineurin-immunopositive cells, indicated breakdown of cell membranes symptomatic of incipient cell death. The local application of the calcineurin inhibitors, FK506 and cyclosporin A, reduced the level of noise-induced auditory brain stem response threshold shift and hair cell death, indicating that calcineurin is a factor in noise-induced hearing loss. The results suggest that calcineurin inhibitors are of potential therapeutic value for long-term protection of the morphologic integrity and function of the organ of Corti against noise trauma. © 2004 Wiley-Liss, Inc. | en_US |
dc.format.extent | 582043 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Calcineurin activation contributes to noise-induced hearing loss | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan ; Department of Otolaryngology, Keio University Hospital, Tokyo, Japan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan ; Center for Hearing and Communication, Karolinska Institutet, Stockholm, Sweden ; Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506 | en_US |
dc.identifier.pmid | 15389832 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34869/1/20267_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jnr.20267 | en_US |
dc.identifier.source | Journal of Neuroscience Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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