Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
dc.contributor.author | Parent, Jack M. | en_US |
dc.contributor.author | Vexler, Zinaida S. | en_US |
dc.contributor.author | Gong, Chao | en_US |
dc.contributor.author | Derugin, Nikita | en_US |
dc.contributor.author | Ferriero, Donna M. | en_US |
dc.date.accessioned | 2006-04-19T13:56:44Z | |
dc.date.available | 2006-04-19T13:56:44Z | |
dc.date.issued | 2002-12 | en_US |
dc.identifier.citation | Parent, Jack M.; Vexler, Zinaida S.; Gong, Chao; Derugin, Nikita; Ferriero, Donna M. (2002)."Rat forebrain neurogenesis and striatal neuron replacement after focal stroke." Annals of Neurology 52(6): 802-813. <http://hdl.handle.net/2027.42/34890> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34890 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12447935&dopt=citation | en_US |
dc.description.abstract | The persistence of neurogenesis in the forebrain subventricular zone (SVZ) of adult mammals suggests that the mature brain maintains the potential for neuronal replacement after injury. We examined whether focal ischemic injury in adult rat would increase SVZ neurogenesis and direct migration and neuronal differentiation of endogenous precursors in damaged regions. Focal stroke was induced in adult rats by 90-minute right middle cerebral artery occlusion (tMCAO). Cell proliferation and neurogenesis were assessed with bromodeoxyuridine (BrdU) labeling and immunostaining for cell type-specific markers. Brains examined 10–21 days after stroke showed markedly increased SVZ neurogenesis and chains of neuroblasts extending from the SVZ to the peri-infarct striatum. Many BrdU-labeled cells persisted in the striatum and cortex adjacent to infarcts, but at 35 days after tMCAO only BrdU-labeled cells in the neostriatum expressed neuronal markers. Newly generated cells in the injured neostriatum expressed markers of medium spiny neurons, which characterize most neostriatal neurons lost after tMCAO. These findings indicate that focal ischemic injury increases SVZ neurogenesis and directs neuroblast migration to sites of damage. Moreover, neuroblasts in the injured neostriatum appear to differentiate into a region-appropriate phenotype, which suggests that the mature brain is capable of replacing some neurons lost after ischemic injury. | en_US |
dc.format.extent | 1573192 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Rat forebrain neurogenesis and striatal neuron replacement after focal stroke | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI Departments of ; Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109-0585 | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI Departments of | en_US |
dc.contributor.affiliationother | Department of Neurology, University of California, San Francisco, San Francisco, CA ; Department of Pediatrics, University of California, San Francisco, San Francisco, CA | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, University of California, San Francisco, San Francisco, CA | en_US |
dc.contributor.affiliationother | Department of Neurology, University of California, San Francisco, San Francisco, CA ; Department of Pediatrics, University of California, San Francisco, San Francisco, CA | en_US |
dc.identifier.pmid | 12447935 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34890/1/10393_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.10393 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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