Distribution and dynamics of laser-polarized 129 Xe magnetization in vivo
dc.contributor.author | Swanson, Scott D. | en_US |
dc.contributor.author | Rosen, Matthew S. | en_US |
dc.contributor.author | Coulter, Kevin P. | en_US |
dc.contributor.author | Welsh, Robert C. | en_US |
dc.contributor.author | Chupp, Timothy E. | en_US |
dc.date.accessioned | 2006-04-19T13:59:12Z | |
dc.date.available | 2006-04-19T13:59:12Z | |
dc.date.issued | 1999-12 | en_US |
dc.identifier.citation | Swanson, Scott D.; Rosen, Matthew S.; Coulter, Kevin P.; Welsh, Robert C.; Chupp, Timothy E. (1999)."Distribution and dynamics of laser-polarized 129 Xe magnetization in vivo." Magnetic Resonance in Medicine 42(6): 1137-1145. <http://hdl.handle.net/2027.42/34928> | en_US |
dc.identifier.issn | 0740-3194 | en_US |
dc.identifier.issn | 1522-2594 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34928 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10571936&dopt=citation | en_US |
dc.description.abstract | The first magnetic resonance imaging studies of laser-polarized 129 Xe, dissolved in the blood and tissue of the lungs and the heart of Sprague-Dawley rats, are described. 129 Xe resonances at 0, 192, 199, and 210 ppm were observed and assigned to xenon in gas, fat, tissue, and blood, respectively. One-dimensional chemical-shift imaging (CSI) reveals xenon magnetization in the brain, kidney, and lungs. Coronal and axial two-dimensional CSI show 129 Xe dissolved in blood and tissue in the thorax. Images of the blood resonance show xenon in the lungs and the heart ventricle. Images of the tissue resonance reveal xenon in lung parenchyma and myocardium. The 129 Xe spectrum from a voxel located in the heart ventricle shows a single blood resonance. Time-resolved spectroscopy shows that the dynamics of the blood resonance match the dynamics of the gas resonance and demonstrates efficient diffusion of xenon gas to the lung parenchyma and then to pulmonary blood. These observations demonstrate the utility of laser-polarized 129 Xe to detect exchange across the gas-blood barrier in the lungs and perfusion into myocardial tissue. Applications to measurement of lung function, kidney perfusion, myocardial perfusion, and regional cerebral blood flow are discussed. Magn Reson Med 42:1137–1145, 1999. © 1999 Wiley-Liss, Inc. | en_US |
dc.format.extent | 444514 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Distribution and dynamics of laser-polarized 129 Xe magnetization in vivo | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan, Ann Arbor, Michigan. ; Department of Radiology, The University of Michigan, Ann Arbor, MI 48109-0553. | en_US |
dc.contributor.affiliationum | Department of Physics, The University of Michigan, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Physics, The University of Michigan, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Physics, The University of Michigan, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Department of Physics, The University of Michigan, Ann Arbor, Michigan. | en_US |
dc.identifier.pmid | 10571936 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34928/1/19_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1522-2594(199912)42:6<1137::AID-MRM19>3.0.CO;2-4 | en_US |
dc.identifier.source | Magnetic Resonance in Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.