Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma
dc.contributor.author | Schepkin, Victor D. | en_US |
dc.contributor.author | Ross, Brian D. | en_US |
dc.contributor.author | Chenevert, Thomas L. | en_US |
dc.contributor.author | Rehemtulla, Alnawaz | en_US |
dc.contributor.author | Sharma, Surabhi | en_US |
dc.contributor.author | Kumar, Mahesh | en_US |
dc.contributor.author | Stojanovska, Jadranka | en_US |
dc.date.accessioned | 2006-04-19T13:59:21Z | |
dc.date.available | 2006-04-19T13:59:21Z | |
dc.date.issued | 2005-01 | en_US |
dc.identifier.citation | Schepkin, Victor D.; Ross, Brian D.; Chenevert, Thomas L.; Rehemtulla, Alnawaz; Sharma, Surabhi; Kumar, Mahesh; Stojanovska, Jadranka (2005)."Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma." Magnetic Resonance in Medicine 53(1): 85-92. <http://hdl.handle.net/2027.42/34931> | en_US |
dc.identifier.issn | 0740-3194 | en_US |
dc.identifier.issn | 1522-2594 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34931 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15690506&dopt=citation | en_US |
dc.description.abstract | This study investigates the comparative changes in the sodium MRI signal and proton diffusion following treatment using a 9L rat glioma model to develop markers of earliest response to cancer therapy. Sodium MRI and proton diffusion mapping were performed on untreated ( n = 5) and chemotherapy 1,3-bis(2-chloroethyl)-1-nitrosourea-treated rats ( n = 5). Animals were scanned serially at 2- to 3-day intervals for up to 30 days following therapy. The time course of Na concentration in a tumor showed a dramatic increase in the treated brain tumor compared to the untreated tumor, which correlates in time with an increase in tumor water diffusion. The largest posttreatment increase in sodium signal occurred 7–9 days following treatment and correlated to the period of the greatest chemotherapy-induced cellular necrosis based on diffusion and histopathology. Both Na MRI and proton ADC mapping revealed early changes in tumor sodium content and cellularity. This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity. Magn Reson Med 53:85–92, 2005. © 2004 Wiley-Liss, Inc. | en_US |
dc.format.extent | 493761 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan ; Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Kresge II Research Building, R3028, 200 Zina Pitcher Place, Ann Arbor, MI 48109-0503 | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 15690506 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34931/1/20332_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mrm.20332 | en_US |
dc.identifier.source | Magnetic Resonance in Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.