Effects of estrogen agonists on amphetamine-stimulated striatal dopamine release
dc.contributor.author | Xiao, Li | en_US |
dc.contributor.author | Becker, Jill B. | en_US |
dc.date.accessioned | 2006-04-19T14:02:23Z | |
dc.date.available | 2006-04-19T14:02:23Z | |
dc.date.issued | 1998-08 | en_US |
dc.identifier.citation | Xiao, Li; Becker, Jill B. (1998)."Effects of estrogen agonists on amphetamine-stimulated striatal dopamine release." Synapse 29(4): 379-391. <http://hdl.handle.net/2027.42/34982> | en_US |
dc.identifier.issn | 0887-4476 | en_US |
dc.identifier.issn | 1098-2396 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34982 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9661256&dopt=citation | en_US |
dc.description.abstract | Based upon the observation that estrogen acts in the striatum to rapidly modulate dopamine (DA) neural transmission and DA-mediated behaviors, it has been postulated that these effects of estrogen are mediated by a specific, membrane-bound receptor mechanism. To further characterize the pharmacological specificity of the estrogen binding site, the present experiments examine effects of various estrogen agonists on amphetamine (AMPH)-induced DA release from striatal tissue of ovariectomized female rats, using a superfusion method. Catechol estrogens 4-, and 2-hydroxyestradiol, but not 2-methoxyestradiol, significantly enhance AMPH-induced striatal DA release. Estrogen metabolites, estrone and estriol, and the non-steroidal estrogen analog, diethylstilbestrol, are without effects. Estradiol conjugated to bovine serum albumin (BSA) mimics the effect of estradiol to enhance stimulated striatal DA release. These results indicate that the steroidal configuration and hydroxylation on the A-ring of estrogenic compounds may be important determinants of ligand binding to the putative estrogen binding site in the striatum. Furthermore, the effectiveness of the estradiol conjugated to BSA reinforces the idea of an external membrane-bound receptor binding site in the striatum. Synapse 29:379–391, 1998. © 1998 Wiley-Liss, Inc. | en_US |
dc.format.extent | 156952 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Effects of estrogen agonists on amphetamine-stimulated striatal dopamine release | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48109–1109 ; Reproductive Sciences Program, The University of Michigan, Ann Arbor, Michigan 48109–1109 | en_US |
dc.contributor.affiliationum | Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48109–1109 ; Reproductive Sciences Program, The University of Michigan, Ann Arbor, Michigan 48109–1109 ; Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109–1109 ; Psychology Department, Biopsychology Area, 525 East University, Ann Arbor, MI 48109–1109. E-mail: jbecker@umich.edu | en_US |
dc.identifier.pmid | 9661256 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34982/1/10_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1098-2396(199808)29:4<379::AID-SYN10>3.0.CO;2-M | en_US |
dc.identifier.source | Synapse | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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