Reduced MPTP neurotoxicity in striatum of the mutant mouse tottering
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Sherman, Phillip S. | en_US |
dc.contributor.author | Abbott, Louise C. | en_US |
dc.date.accessioned | 2006-04-19T14:02:26Z | |
dc.date.available | 2006-04-19T14:02:26Z | |
dc.date.issued | 1998-10 | en_US |
dc.identifier.citation | Kilbourn, Michael R.; Sherman, Phillip; Abbott, Louise C. (1998)."Reduced MPTP neurotoxicity in striatum of the mutant mouse tottering ." Synapse 30(2): 205-210. <http://hdl.handle.net/2027.42/34983> | en_US |
dc.identifier.issn | 0887-4476 | en_US |
dc.identifier.issn | 1098-2396 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34983 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9723790&dopt=citation | en_US |
dc.description.abstract | The effects of MPTP treatment (4 × 10 mg/kg, 2-h intervals) on in vivo striatal binding of (+)-α-[ 3 H]dihydrotetrabenazine ((+)-[ 3 H]DTBZ) to the vesicular monoamine transporter type 2 (VMAT2) were examined in wild type ( +,+ ) and tottering ( tg/tg ) mice of the C57BL/6J strain. The tottering mutant has been previously characterized as having hyperinnervation of noradrenergic terminals in the brain, with increased concentrations of norepinephrine and increased numbers of VMAT2 binding sites. In wild-type mice, MPTP caused a significant decrease in specific striatal (+)-[ 3 H]DTBZ binding in both males (-71%) and females (-57%), consistent with dopaminergic terminal losses. In the tottering mice, the neurotoxic effects of MPTP were diminished, with smaller losses of (+)-[ 3 H]DTBZ binding observed both in males (-45%) and females (-26%). These results are consistent with the hypothesis that vesicular storage (as a result of hyperinnervation) offers neuroprotection toward MPTP toxicity, although the confounding effects of increases in norepinephrine concentrations or changes in calcium ion channel function (both also characteristics of the tottering mutant) cannot be ruled out. The tottering mutant does, however, offer another animal model to examine the biochemical features responsible for MPTP toxicity. Synapse 30:205–210, 1998. © 1998 Wiley-Liss, Inc. | en_US |
dc.format.extent | 94624 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Reduced MPTP neurotoxicity in striatum of the mutant mouse tottering | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; University of Michigan, Ann Arbor, MI 48109. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station, Texas | en_US |
dc.identifier.pmid | 9723790 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34983/1/10_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1098-2396(199810)30:2<205::AID-SYN10>3.0.CO;2-0 | en_US |
dc.identifier.source | Synapse | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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