Ionotropic glutamate receptor modulation preferentially affects NMDA receptor expression in rat hippocampus
dc.contributor.author | Healy, Daniel J. | en_US |
dc.contributor.author | Meador-Woodruff, James H. | en_US |
dc.date.accessioned | 2006-04-19T14:02:48Z | |
dc.date.available | 2006-04-19T14:02:48Z | |
dc.date.issued | 2000-12-01 | en_US |
dc.identifier.citation | Healy, Daniel J.; Meador-Woodruff, James H. (2000)."Ionotropic glutamate receptor modulation preferentially affects NMDA receptor expression in rat hippocampus." Synapse 38(3): 294-304. <http://hdl.handle.net/2027.42/34990> | en_US |
dc.identifier.issn | 0887-4476 | en_US |
dc.identifier.issn | 1098-2396 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34990 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11020232&dopt=citation | en_US |
dc.description.abstract | Electrophysiological data suggest that alterations in the function of one glutamate receptor subtype may affect the function of other subtypes. Further, previous studies have demonstrated that NMDA receptor antagonists affect NMDA and kainate receptor expression in rat hippocampus. In order to address the mutual regulation of NMDA, AMPA, and kainate receptor expression in rat hippocampus, we conducted two experiments examining the effects of NMDA and non-NMDA glutamate receptor modulators on NMDA, AMPA, and kainate receptor expression using in situ hybridization and receptor autoradiography. NMDA receptor expression was preferentially affected by systemic treatments, as all drugs significantly altered [ 3 H]MK-801 binding, and several drugs increased [ 3 H]ifenprodil binding. GYKI52466 and aniracetam treatments resulted in changes in both [ 3 H]ifenprodil binding and NR2B mRNA levels, consistent with the association of this subunit and binding site in vitro. There were more modest effects on AMPA and kainate receptor expression, even by direct antagonists. Together, these data suggest that ionotropic glutamate receptors interact at the level of expression. These data also suggest that drug regimens targeting one ionotropic glutamate receptor subtype may indirectly affect other subtypes, potentially producing unwanted side effects. Synapse 38:294–304, 2000. © 2000 Wiley-Liss, Inc. | en_US |
dc.format.extent | 310941 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Ionotropic glutamate receptor modulation preferentially affects NMDA receptor expression in rat hippocampus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan ; Mental Health Research Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720 | en_US |
dc.identifier.pmid | 11020232 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34990/1/8_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/1098-2396(20001201)38:3<294::AID-SYN8>3.0.CO;2-U | en_US |
dc.identifier.source | Synapse | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.