Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population

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dc.contributor.author Nepomnaschy, Pablo A. en_US
dc.contributor.author Welch, Kathy en_US
dc.contributor.author McConnell, Daniel S. en_US
dc.contributor.author Strassmann, Beverly I. en_US
dc.contributor.author England, Barry G. en_US
dc.date.accessioned 2006-04-19T14:09:58Z
dc.date.available 2006-04-19T14:09:58Z
dc.date.issued 2004-09 en_US
dc.identifier.citation Nepomnaschy, Pablo A.; Welch, Kathy; McConnell, Dan; Strassmann, Beverly I.; England, Barry G. (2004)."Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population." American Journal of Human Biology 16(5): 523-532. <http://hdl.handle.net/2027.42/35107> en_US
dc.identifier.issn 1042-0533 en_US
dc.identifier.issn 1520-6300 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/35107
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15368600&dopt=citation en_US
dc.description.abstract We report here on a longitudinal study of stress and women's reproduction in a small Kaqchikel Mayan community in rural Guatemala. Current understanding of the effects of stress on the reproductive axis in women is mostly derived from clinical studies of individual stressors. Little is known, however, about the cumulative effects of “real life” stress. Cortisol increases in response to a broad variety of individual stressors (Tilbrook et al., 2002). In this article, we evaluate the association between daily fluctuations in women's urinary cortisol and reproductive hormones: estrone conjugates (E 1 C), pregnandiol glucuronide (PdG), luteinizing hormone (LH), and follicle stimulating hormone (FSH). To assess the association between daily changes in cortisol levels and changes in the profiles of the reproductive hormones, we used a random coefficients model based on polynomial regression. The sample includes 92 menstrual cycles provided by 24 participants over a year-long prospective study. Increases in urinary cortisol levels were associated with significant increases in gonadotrophin and progestin levels during the follicular phase. Also, in a time window between days 4 and 10 after ovulation, increased cortisol levels were associated with significantly lower progestin levels. These results are significant because untimely increases in gonadotrophins and low midluteal progesterone levels have previously been reported to impinge on the ovulatory and luteinization processes and to reduce the chances of successful implantation (Ferin, 1999; Baird et al., 1999). Future research should consider the possibility that stress may affect fecundability and implantation without necessarily causing amenorrhoea or oligomenorrhoea. Am. J. Hum. Biol. 16:523–532, 2004. © 2004 Wiley-Liss, Inc. en_US
dc.format.extent 135010 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Anthropology en_US
dc.title Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Medicine (General) en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Anthropology, The University of Michigan, Ann Arbor, Michigan 48109 ; Reproductive Sciences Program, The University of Michigan, Ann Arbor, Michigan 48109 ; Department of Anthropology, 101 West Hall, The University of Michigan, Ann Arbor, MI 48109-1092 en_US
dc.contributor.affiliationum Center for Statistical Consultation and Research, The University of Michigan, Ann Arbor, Michigan 48109 en_US
dc.contributor.affiliationum Reproductive Sciences Program, The University of Michigan, Ann Arbor, Michigan 48109 ; Department of Epidemiology, The University of Michigan, Ann Arbor, Michigan 48109 en_US
dc.contributor.affiliationum Department of Anthropology, The University of Michigan, Ann Arbor, Michigan 48109 en_US
dc.contributor.affiliationum Reproductive Sciences Program, The University of Michigan, Ann Arbor, Michigan 48109 ; Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109 en_US
dc.identifier.pmid 15368600 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/35107/1/20057_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/ajhb.20057 en_US
dc.identifier.source American Journal of Human Biology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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