Ancient origins of human developmental plasticity
dc.contributor.author | Crespi, Erica J. | en_US |
dc.contributor.author | Denver, Robert John | en_US |
dc.date.accessioned | 2006-04-19T14:10:01Z | |
dc.date.available | 2006-04-19T14:10:01Z | |
dc.date.issued | 2005-01 | en_US |
dc.identifier.citation | Crespi, Erica J.; Denver, Robert J. (2005)."Ancient origins of human developmental plasticity." American Journal of Human Biology 17(1): 44-54. <http://hdl.handle.net/2027.42/35108> | en_US |
dc.identifier.issn | 1042-0533 | en_US |
dc.identifier.issn | 1520-6300 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35108 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15611964&dopt=citation | en_US |
dc.description.abstract | Animals have the ability to alter development, physiology, growth, and behavior in response to different environmental conditions. These responses represent critical assessments of both external and internal factors. For example, the timing of metamorphosis, hatching, or birth depends on the trade-offs between growth opportunity and mortality risk in the developmental habitat. Physiological sensors compute these trade-offs as a function of energy balance and environmental stress, and effectors initiate physiological, developmental, and behavioral responses to these determinations. The neuroendocrine stress axis provides a means for animals to integrate information from multiple sources and to respond accordingly. Considerable evidence now supports the view that the secretion of hormones critical to development (corticosteroid and thyroid hormones) is controlled by a common neuroendocrine stress pathway involving corticotropin-releasing factor (CRF) and related peptides. CRF produced in the hypothalamus stimulates the biosynthesis and secretion of both thyroid and corticosteroid hormones, leading to accelerated tadpole metamorphosis. Similarly, in mammals CRF of fetal and placental origin has been shown to influence the timing of birth. Studies in several experimental animal models and in humans show that early life experience can have long-term phenotypic consequences. Furthermore, there is evidence that phenotypic expression is strongly influenced by the actions of stress hormones produced during development. The integrated neuroendocrine response to stress, and its role in timing critical life history transitions and establishing long-term phenotypic expression, arose early in the evolution of vertebrates. Am. J. Hum. Biol. 17:44–54, 2005. © 2004 Wiley-Liss, Inc. | en_US |
dc.format.extent | 149397 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Anthropology | en_US |
dc.title | Ancient origins of human developmental plasticity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 ; Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, Michigan 48109 ; Department of Molecular, Cellular and Developmental Biology, 3065C Natural Science Building, The University of Michigan, Ann Arbor, MI 48109-1048 | en_US |
dc.identifier.pmid | 15611964 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35108/1/20098_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ajhb.20098 | en_US |
dc.identifier.source | American Journal of Human Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.