Human papillomavirus infection in “young” versus “old” patients with squamous cell carcinoma of the head and neck
dc.contributor.author | Sisk, Elizabeth A. | en_US |
dc.contributor.author | Bradford, Carol R. | en_US |
dc.contributor.author | Jacob, Abraham | en_US |
dc.contributor.author | Yian, Christopher H. | en_US |
dc.contributor.author | Staton, Kim M. | en_US |
dc.contributor.author | Tang, Gong | en_US |
dc.contributor.author | Harris, Monte O. | en_US |
dc.contributor.author | Carey, Thomas E. | en_US |
dc.contributor.author | Lancaster, Wayne D. | en_US |
dc.contributor.author | Gregoire, Lucie | en_US |
dc.date.accessioned | 2006-04-19T14:10:22Z | |
dc.date.available | 2006-04-19T14:10:22Z | |
dc.date.issued | 2000-10 | en_US |
dc.identifier.citation | Sisk, Elizabeth A.; Bradford, Carol R.; Jacob, Abraham; Yian, Christopher H.; Staton, Kim M.; Tang, Gong; Harris, Monte O.; Carey, Thomas E.; Lancaster, Wayne D.; Gregoire, Lucie (2000)."Human papillomavirus infection in “young” versus “old” patients with squamous cell carcinoma of the head and neck." Head & Neck 22(7): 649-657. <http://hdl.handle.net/2027.42/35115> | en_US |
dc.identifier.issn | 1043-3074 | en_US |
dc.identifier.issn | 1097-0347 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35115 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11002318&dopt=citation | en_US |
dc.description.abstract | Background Human papillomavirus (HPV) represents a potential risk factor for squamous cell cancer of the head and neck (SCCHN). We evaluated the prevalence of HPV DNA in patients with SCCHN diagnosed at the University of Michigan from 1994–1996. Methods Patients were stratified by age at diagnosis as “young” (<50 years; median, 39) or “old” (>50 years; median, 66). Fourteen “young” and 14 “old” were matched for tumor site, and 4 additional “old” patients were included. Specimens were analyzed by polymerase chain reaction for HPV DNA using 2 sets of consensus primers. HPV sequences were confirmed by Southern blot hybridization and typed with type-specific probes. Results Overall, 15 of 32 (46.9%) samples contained HPV sequences. HPV 16 was detected in 9 of 15 (60%), HPV-18 in 1 of 15 (6.6%), and 5 of 15 (33.3%) remained untyped by multiple methods. When stratified, 7 of 14 (50%) “young” were HPV-positive compared with 8 of 18 (44.4%) “old” ( p = .76). Survival in patients with HPV-positive SCCHN was significantly longer than that for HPV-negative patients. Conclusions The incidence of HPV in “young” versus “old” is not significantly different, suggesting similar roles for both groups. Patients with HPV-positive tumors may have a survival advantage relative to patients with HPV-negative tumors. © 2000 John Wiley & Sons, Inc. Head Neck 22: 649–657, 2000. | en_US |
dc.format.extent | 269361 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Human papillomavirus infection in “young” versus “old” patients with squamous cell carcinoma of the head and neck | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 ; Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Biostatistics, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201 ; Center for Molecular Genetics, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Center for Molecular Genetics, Wayne State University, Detroit, Michigan | en_US |
dc.identifier.pmid | 11002318 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35115/1/2_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/1097-0347(200010)22:7<649::AID-HED2>3.0.CO;2-B | en_US |
dc.identifier.source | Head & Neck | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.