P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines Presented at the American Association of Cancer Research 91st Annual Meeting, San Francisco, California, April 1–5, 2000.

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dc.contributor.author Bradford, Carol R. en_US
dc.contributor.author Zhu, Shaobo en_US
dc.contributor.author Ogawa, Haruko en_US
dc.contributor.author Ogawa, Tetsuya en_US
dc.contributor.author Ubell, Matthew en_US
dc.contributor.author Narayan, Ajita en_US
dc.contributor.author Johnson, Garfield en_US
dc.contributor.author Wolf, Gregory T. en_US
dc.contributor.author Fisher, Susan G. en_US
dc.contributor.author Carey, Thomas E. en_US
dc.date.accessioned 2006-04-19T14:11:23Z
dc.date.available 2006-04-19T14:11:23Z
dc.date.issued 2003-08 en_US
dc.identifier.citation Bradford, Carol R.; Zhu, Shaobo; Ogawa, Haruko; Ogawa, Tetsuya; Ubell, Matthew; Narayan, Ajita; Johnson, Garfield; Wolf, Gregory T.; Fisher, Susan G.; Carey, Thomas E. (2003)."P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines Presented at the American Association of Cancer Research 91st Annual Meeting, San Francisco, California, April 1–5, 2000. ." Head & Neck 25(8): 654-661. <http://hdl.handle.net/2027.42/35126> en_US
dc.identifier.issn 1043-3074 en_US
dc.identifier.issn 1097-0347 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/35126
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12884349&dopt=citation en_US
dc.description.abstract Background. A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. Previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did not overexpress p53. Methods. To determine the relationship of p53 mutations to sensitivity to cisplatin in vitro, 23 head and neck squamous cell carcinoma (HNSCC) cell lines were analyzed for cisplatin sensitivity, p53 expression, and p53 mutation status. Results. Mutations of the p53 gene were identified in 13 of 23 of the cell lines tested. Mutation of the p53 gene was significantly associated with high levels of expression of the p53 protein. The average ID 50 (drug dose required to inhibit 50% of cell growth) for cell lines with mutant p53 was 6.8 ΜM, whereas the average ID 50 for cell lines with wild-type p53 was 13.7 ΜM. Conclusions. These in vitro data support a role for mutation of the p53 tumor suppressor gene as a marker for response to cisplatin in HNSCC. © 2003 Wiley Periodicals, Inc. Head Neck 25: 654–661, 2003 en_US
dc.format.extent 142552 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cancer Research, Oncology and Pathology en_US
dc.title P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines Presented at the American Association of Cancer Research 91st Annual Meeting, San Francisco, California, April 1–5, 2000. en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Otolaryngology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 ; Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationum Department of Otolaryngology–Head and Neck Surgery, 1904 Taubman Center, University of Michigan, Ann Arbor, Michigan 48109-0312 en_US
dc.contributor.affiliationother Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois en_US
dc.identifier.pmid 12884349 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/35126/1/10274_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/hed.10274 en_US
dc.identifier.source Head & Neck en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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