Haploinsufficiency and reduced expression of genes localized to the 8p chromosomal region in human prostate tumors
dc.contributor.author | Chaib, Hassan | en_US |
dc.contributor.author | MacDonald, James W. | en_US |
dc.contributor.author | Vessella, Robert L. | en_US |
dc.contributor.author | Washburn, Joseph G. | en_US |
dc.contributor.author | Quinn, Janna E. | en_US |
dc.contributor.author | Odman, Austin M. | en_US |
dc.contributor.author | Rubin, Mark A. | en_US |
dc.contributor.author | Macoska, Jill A. | en_US |
dc.date.accessioned | 2006-04-19T14:11:48Z | |
dc.date.available | 2006-04-19T14:11:48Z | |
dc.date.issued | 2003-07 | en_US |
dc.identifier.citation | Chaib, Hassan; MacDonald, James W.; Vessella, Robert L.; Washburn, Joseph G.; Quinn, Janna E.; Odman, Austin; Rubin, Mark A.; Macoska, Jill A. (2003)."Haploinsufficiency and reduced expression of genes localized to the 8p chromosomal region in human prostate tumors." Genes, Chromosomes and Cancer 37(3): 306-313. <http://hdl.handle.net/2027.42/35134> | en_US |
dc.identifier.issn | 1045-2257 | en_US |
dc.identifier.issn | 1098-2264 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35134 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12759929&dopt=citation | en_US |
dc.description.abstract | Cytogenetic and molecular studies have suggested that deletion or rearrangement of sequences that map to the short arm of chromosome 8 may be permissive for tumorigenesis in several organ systems, and in human prostate tumors in particular. In this study, we hypothesized that genes deleted for one copy and localized to the 8p chromosomal region may be transcriptionally down-regulated or ablated in affected human prostate tumor tissues. To test this hypothesis, we used cDNA microarray analysis to determine the transcriptional profiles for 259 transcribed sequences mapping to the 8p chromosomal region for seven human prostate tumor xenografts, completely characterized for numerical and structural alterations on chromosome 8, and five normal human prostate tissues. These experiments identified 33 genes differentially expressed between normal and malignant prostate tissues, the majority of which (28/33, 85%) were transcriptionally down-regulated in malignant compared to normal human prostate tissues. These findings, that haploinsufficiency and transcriptional down-regulation for genes mapping to 8p are largely coincident in human prostate tumors, should provide a powerful tool for the identification of tumor-suppressor genes associated with human prostate cancer initiation and progression. © 2003 Wiley-Liss, Inc. | en_US |
dc.format.extent | 338031 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Haploinsufficiency and reduced expression of genes localized to the 8p chromosomal region in human prostate tumors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Urology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | The Comprehensive Cancer Center cDNA and Affymetrix Microarray Core, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | The Comprehensive Cancer Center cDNA and Affymetrix Microarray Core, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, The University of Michigan, Ann Arbor, Michigan ; Department of Pathology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, The University of Michigan, Ann Arbor, Michigan ; The Comprehensive Cancer Center cDNA and Affymetrix Microarray Core, The University of Michigan, Ann Arbor, Michigan ; Department of Urology, The University of Michigan, 7306 CCGC, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0946 | en_US |
dc.contributor.affiliationother | Department of Urology, The University of Washington, Seattle, Washington | en_US |
dc.contributor.affiliationother | Department of Urology, The University of Washington, Seattle, Washington | en_US |
dc.contributor.affiliationother | Department of Urology, The University of Washington, Seattle, Washington | en_US |
dc.identifier.pmid | 12759929 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35134/1/10226_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/gcc.10226 | en_US |
dc.identifier.source | Genes, Chromosomes and Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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