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Expression of ZIC genes in the development of the chick inner ear and nervous system

dc.contributor.authorWarner, Stephen J.en_US
dc.contributor.authorHutson, Mary R.en_US
dc.contributor.authorOh, Seung-Haen_US
dc.contributor.authorGerlach-Bank, Lisa M.en_US
dc.contributor.authorLomax, Margaret I.en_US
dc.contributor.authorBarald, Kate F.en_US
dc.date.accessioned2006-04-19T14:14:45Z
dc.date.available2006-04-19T14:14:45Z
dc.date.issued2003-04en_US
dc.identifier.citationWarner, Stephen J.; Hutson, Mary R.; Oh, Seung-Ha; Gerlach-Bank, Lisa M.; Lomax, Margaret I.; Barald, Kate F. (2003)."Expression of ZIC genes in the development of the chick inner ear and nervous system." Developmental Dynamics 226(4): 702-712. <http://hdl.handle.net/2027.42/35173>en_US
dc.identifier.issn1058-8388en_US
dc.identifier.issn1097-0177en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/35173
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12666207&dopt=citationen_US
dc.description.abstractZIC genes, vertebrate homologues of the Drosophila pair-rule gene odd-paired ( opa ), function in embryonic pattern formation, in the early stages of central nervous system neurogenesis and in cerebellar maturation. Mouse Zic genes are expressed in restricted, and in some cases overlapping, patterns during development, particularly in the central and peripheral nervous systems. We identified chick ZIC2 in a differential display analysis of the auditory system designed to find genes up-regulated after noise trauma. In this study, we examined the expression of chick ZIC1 , ZIC2 , and ZIC3 by in situ hybridization in normal inner ear development and in the tissues that influence its development, including the hindbrain, the neural crest, and the periotic mesenchyme. Between Hamburger and Hamilton stages 13 and 24, all three ZIC genes were found in the dorsal periotic mesenchyme adjacent to the developing inner ear. ZIC1 mRNA was expressed in the otocyst epithelium between stages 12 and 24, in some sensory tissue, as well as in a striped pattern in the floorplate of the hindbrain that appears to be complementary to that of Chordin, a gene known to regulate ZIC expression in frogs. Chick ZIC genes are also expressed in the neuroectoderm, paraxial mesenchyme, brain, spinal cord, neural crest, and/or the overlying ectoderm as well as the limb buds. In general, ZIC1 and ZIC2 expression patterns overlapped, although ZIC2 expression was less robust; ZIC3 expression was minimal. These observations suggest that ZIC genes, in addition to their known roles in brain development, may play an important role in the development of the chick inner ear. Developmental Dynamics 702–712, 2003. © 2003 Wiley-Liss, Inc.en_US
dc.format.extent918856 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleExpression of ZIC genes in the development of the chick inner ear and nervous systemen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Chongno-ku, Seoul, Koreaen_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan ; Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan ; Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan ; University of Michigan Medical School, Department of Cell and Developmental Biology, Box 0616, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0616en_US
dc.identifier.pmid12666207en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/35173/1/10262_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/dvdy.10262en_US
dc.identifier.sourceDevelopmental Dynamicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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