III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung
dc.contributor.author | Matsukawa, Akihiro | en_US |
dc.contributor.author | Lukacs, Nicholas W. | en_US |
dc.contributor.author | Hogaboam, Cory M. | en_US |
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-04-19T14:15:17Z | |
dc.date.available | 2006-04-19T14:15:17Z | |
dc.date.issued | 2001-05-15 | en_US |
dc.identifier.citation | Matsukawa, Akihiro; Lukacs, Nicholas W.; Hogaboam, Cory M.; Chensue, Stephen W.; Kunkel, Steven L. (2001)."III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung." Microscopy Research and Technique 53(4): 298-306. <http://hdl.handle.net/2027.42/35184> | en_US |
dc.identifier.issn | 1059-910X | en_US |
dc.identifier.issn | 1097-0029 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35184 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11340675&dopt=citation | en_US |
dc.description.abstract | Chemokines constitute a large family of chemotactic cytokines that belong to a super-gene family of 8–10 kDa proteins. The chemokines are considered to be primarily beneficial in host defense against invading pathogens. However, the reactions induced by chemokines can be occasionally excessive, resulting in a harmful response to the host. Recent studies in chemokine biology have elucidated that chemokines are involved in the initiation, development, and maintenance of numbers of diseases including lung diseases. In addition to its chemotactic activity, evidence suggests that chemokines can modify the outcome of the cell-mediated immune responses by altering the Th1/Th2 cytokine profile. Chemokines are also capable of dictating the direction of specific immune responses. Chemokine action is mediated by a large super-family of G-protein coupled receptors, and the receptors are preferentially expressed on Th1/Th2 cells. Certain chemokine receptors are constitutively expressed in immune surveying cells such as dendritic cells and naive T cells. The corresponding chemokines are present in normal lymphoid tissues, suggesting a role of chemokines/receptors in cell homing and cell-cell communication in lymphoid tissue that can be an initial step for immune recognition. Thus, comprehension of the chemokine biology in immune responses appears to be fundamental for understanding the pathogenesis of T cell–mediated immune responses. The following review will highlight the current insight into the role of chemokines and their receptors in the cell-mediated immune response, with a special focus on lung diseases. Microsc. Res. Tech. 53:298–306, 2001. © 2001 Wiley-Liss, Inc. | en_US |
dc.format.extent | 228740 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 ; Department of Pathology, University of Michigan Medical School, Med Sci I, Rm 5214, 1301 Catherine Rd., Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Department of Pathology, Veteran Affairs Medical Center, Ann Arbor, Michigan 48105 | en_US |
dc.identifier.pmid | 11340675 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35184/1/1096_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jemt.1096 | en_US |
dc.identifier.source | Microscopy Research and Technique | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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