Effect of p53 overexpression on radiation sensitivity of human colon cancer cells
dc.contributor.author | Zellars, Richard C. | en_US |
dc.contributor.author | Naida, John D. | en_US |
dc.contributor.author | Davis, Mary A. | en_US |
dc.contributor.author | Lawrence, Theodore S. | en_US |
dc.date.accessioned | 2006-04-19T14:15:42Z | |
dc.date.available | 2006-04-19T14:15:42Z | |
dc.date.issued | 1997 | en_US |
dc.identifier.citation | Zellars, Richard C.; Naida, John D.; Davis, Mary A.; Lawrence, Theodore S. (1997)."Effect of p53 overexpression on radiation sensitivity of human colon cancer cells." Radiation Oncology Investigations 5(2): 43-49. <http://hdl.handle.net/2027.42/35193> | en_US |
dc.identifier.issn | 1065-7541 | en_US |
dc.identifier.issn | 1520-6823 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35193 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9303056&dopt=citation | en_US |
dc.description.abstract | Substantial controversy surrounds our understanding of the effect of p53 status on radiation sensitivity. To assess directly the role of p53 expression on radiation sensitivity, we chose a conditional expression system using a temperature-sensitive murine p53 that permitted each cell line to act as its own control. We found that the conditional expression of wild type p53 induced cell death (both apoptotic and nonapoptotic), changes in cell cycle distribution (arrest in G 1 and G 2 , which resulted in a marked depletion of S-phase cells and an increase in the fraction of cells in G 2 ), and an increase in the radiation resistance of G 1 cells. These counterbalancing effects resulted in no significant effect on overall radiosensitivity. These findings demonstrate that wild type p53 function can produce a variety of effects that can modulate radiation sensitivity and may explain why p53 status alone has not been a strong predictor of radiosensitivity. Radiat. Oncol. Invest. 5:43–49, 1997. © 1997 Wiley-Liss, Inc. | en_US |
dc.format.extent | 453937 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Effect of p53 overexpression on radiation sensitivity of human colon cancer cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Complementary and Alternative Medicine | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan ; Division of Radiation and Cancer Biology, Department of Radiation Oncology, The University of Michigan, 1331 E. Ann Street, Ann Arbor, MI 48109-0582. | en_US |
dc.identifier.pmid | 9303056 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35193/1/1_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1520-6823(1997)5:2<43::AID-ROI1>3.0.CO;2-J | en_US |
dc.identifier.source | Radiation Oncology Investigations | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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