Bendectin and birth defects II: Ecological analyses
dc.contributor.author | Kutcher, Jeffrey S. | en_US |
dc.contributor.author | Engle, Arnold | en_US |
dc.contributor.author | Firth, Jacqueline | en_US |
dc.contributor.author | Lamm, Steven H. | en_US |
dc.date.accessioned | 2006-04-19T14:21:57Z | |
dc.date.available | 2006-04-19T14:21:57Z | |
dc.date.issued | 2003-02 | en_US |
dc.identifier.citation | Kutcher, Jeffrey S.; Engle, Arnold; Firth, Jacqueline; Lamm, Steven H. (2003)."Bendectin and birth defects II: Ecological analyses." Birth Defects Research Part A: Clinical and Molecular Teratology 67(2): 88-97. <http://hdl.handle.net/2027.42/35295> | en_US |
dc.identifier.issn | 1542-0752 | en_US |
dc.identifier.issn | 1542-0760 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35295 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12769504&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Bendectin was the primary pharmaceutical treatment of nausea and vomiting of pregnancy (NVP) in the United States until the early 1980s. Its manufacture was then discontinued after public allegations that it was causing birth defects. Subsequently, meta-analyses of the many epidemiological cohort and case/control studies used to examine that hypothesis have demonstrated the absence of a detectable teratogenic effect. This study presents an ecological analysis of the same hypothesis that examines specific malformations. METHODS Annual birth defect prevalence data for the 1970s to the 1990s have been obtained for specific birth defects from the Center for Disease Control's nationwide Birth Defect Monitoring Program. These data for the US have been compared graphically to the annual US Bendectin sales for the treatment of NVP. Data have also been obtained for annual US rates for hospitalization for NVP. The three data sets have been temporally compared in graphic analysis. RESULTS The temporal trends in prevalence rates for specific birth defects examined from 1970 through 1992 did not show changes that reflected the cessation of Bendectin use over the 1980–84 period. Further, the NVP hospitalization rate doubled when Bendectin use ceased. CONCLUSIONS The population results of the ecological analyses complement the person-specific results of the epidemiological analyses in finding no evidence of a teratogenic effect from the use of Bendectin. Birth Defects Research (Part A) 67:88–97, 2003. © 2003 Wiley-Liss, Inc. | en_US |
dc.format.extent | 339803 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., a Wiley company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Bendectin and birth defects II: Ecological analyses | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Consultants in Epidemiology and Occupational Health, Inc., Washington, DC 20007 | en_US |
dc.contributor.affiliationother | Tulane University School of Medicine, New Orleans, Louisiana 70112 | en_US |
dc.contributor.affiliationother | Consultants in Epidemiology and Occupational Health, Inc., Washington, DC 20007 ; Consultants in Epidemiology and Occupational Health, Inc., 2428 Wisconsin Ave., NW, Washington, DC 20007 | en_US |
dc.identifier.pmid | 12769504 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35295/1/10034_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bdra.10034 | en_US |
dc.identifier.source | Birth Defects Research Part A: Clinical and Molecular Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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