Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation
dc.contributor.author | Chao, Mwe Mwe | en_US |
dc.contributor.author | Levine, John E. | en_US |
dc.contributor.author | Ruiz, Robert E. | en_US |
dc.contributor.author | Kohlmann, Wendy K. | en_US |
dc.contributor.author | Bower, Matthew A. | en_US |
dc.contributor.author | Petty, Elizabeth M. | en_US |
dc.contributor.author | Mody, Rajen J. | en_US |
dc.date.accessioned | 2006-04-19T14:22:11Z | |
dc.date.available | 2006-04-19T14:22:11Z | |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Chao, Mwe Mwe; Levine, John E.; Ruiz, Robert E.; Kohlmann, Wendy K.; Bower, Matthew A.; Petty, Elizabeth M.; Mody, Rajen J. (2005)."Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation." Pediatric Blood & Cancer 9999(9999): n/a-n/a. <http://hdl.handle.net/2027.42/35300> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35300 | |
dc.description.abstract | We report a 3-year-old boy with a malignant triton tumor (MTT) involving the left masticator space with local invasion and regional lymph node metastasis. Family history and detection of a novel germline TP53 mutation confirmed his diagnosis of Li Fraumeni syndrome (LFS). MTT has not been previously described in association with LFS. This case along with a comprehensive review of the literature, illustrate the importance of both somatic and germline TP53 mutations in the pathogenesis MTT. The tumor could not be resected and he was successfully treated with intensive induction chemotherapy, irradiation, and high-dose chemotherapy with autologous stem cell transplantation. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 276803 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan ; Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan Health System, 1500 East Medical Center Drive, CCGC B1-207, Ann Arbor, MI 48109-0914. | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Internal Medicine-Molecular Medicine and Human Genetics, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Internal Medicine-Molecular Medicine and Human Genetics, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Diagnostic Laboratory, University of Minnesota Medical Center-Fairview, Minneapolis, Minnesota | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35300/1/20700_fta.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.20700 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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