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Connective tissue activation
dc.contributor.authorCastor, C. Williamen_US
dc.contributor.authorScott, Mary E.en_US
dc.contributor.authorRitchie, James C.en_US
dc.contributor.authorHarnsberger, Sandra C.en_US
dc.date.accessioned2006-04-28T16:21:29Z
dc.date.available2006-04-28T16:21:29Z
dc.date.issued1975-09en_US
dc.identifier.citationCastor, C. William; Scott, Mary E.; Ritchie, James C.; Harnsberger, Sandra C. (1975)."Connective tissue activation." Arthritis & Rheumatism 18(5): 451-460. <http://hdl.handle.net/2027.42/37727>en_US
dc.identifier.issn0004-3591en_US
dc.identifier.issn1529-0131en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/37727
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=172091&dopt=citationen_US
dc.description.abstractAlpha- and beta-adrenergic blocking agents and imipramine inhibit the increased hyaluronate synthesis that may be induced in human synovial cultures by connective tissue activating peptide (CTAP). Considerations of drug concentration requirements, actions of analogues, and time studies all indicate that the adrenergic blockers do not act in this circumstance as conventional blockers of alpha or beta receptor sites. It is suggested that the membrane-stabilizing properties of these agents may be the important determinant for their limited “antiactivation” effect. Ethacrynic acid, a potent and more complete inhibitor of connective tissue activation, appears to act via a different mechanism.en_US
dc.format.extent762241 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherRheumatologyen_US
dc.titleConnective tissue activationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumProfessor of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48104.en_US
dc.contributor.affiliationumDepartment of Internal Medicine and the Rackham Arthritis Research Unit, The University of Michigan Medical School, Ann Arbor, Michigan 48104.en_US
dc.contributor.affiliationumDepartment of Internal Medicine and the Rackham Arthritis Research Unit, The University of Michigan Medical School, Ann Arbor, Michigan 48104.en_US
dc.contributor.affiliationumDepartment of Internal Medicine and the Rackham Arthritis Research Unit, The University of Michigan Medical School, Ann Arbor, Michigan 48104.en_US
dc.identifier.pmid172091en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/37727/1/1780180504_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/art.1780180504en_US
dc.identifier.sourceArthritis & Rheumatismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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