Suppression of acute and chronic inflammation by orally administered prostaglandins
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.contributor.author | Ogawa, Hiroshi | en_US |
dc.contributor.author | Conran, Philip B. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.contributor.author | Zurier, Robert B. | en_US |
dc.date.accessioned | 2006-04-28T16:23:02Z | |
dc.date.available | 2006-04-28T16:23:02Z | |
dc.date.issued | 1981-09 | en_US |
dc.identifier.citation | Kunkel, Steven L.; Ogawa, Hiroshi; Conran, Philip B.; Ward, Peter A.; Zurier, Robert B. (1981)."Suppression of acute and chronic inflammation by orally administered prostaglandins." Arthritis & Rheumatism 24(9): 1151-1158. <http://hdl.handle.net/2027.42/37757> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37757 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6458304&dopt=citation | en_US |
dc.description.abstract | Oral administration of a stable analog of prostaglandin E, (PGE 1 ), 15-(S)-15-methyl-prostaglandin E 1 , can suppress both chronic adjuvant-induced polyarthritis and acute immune complex-induced vasculitis in a dose dependent manner. Histopathologic studies of tibiotarsal joints from rats with adjuvant disease showed suppression of arthritis in animals treated with the PGE, analog from time of adjuvant challenge. This study represents the first demonstration of suppressed experimental polyarthritis by an orally administered prostaglandin. Suppression of the acute immune complex-induced vasculitis was demonstrated using 15-methyl-PGE, administered orally 12 hours prior to antigen-antibody challenge. Diminution of tissue injury resulting from immune complex-induced vasculitis is reflected by a decrease in vaso-permeability, indicating suppressed vascular damage in animals treated with prostaglandin. These studies demonstrate the potential use of orally active prostaglandins as an antiinflammatory agent. | en_US |
dc.format.extent | 767937 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Suppression of acute and chronic inflammation by orally administered prostaglandins | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School ; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Pathology, Medical College of Ohio, Toledo, Ohio; and the Department of Medicine, Division of Rheumatology, University of Connecticut, Farmington, Connecticut. ; Department of Pathology, Pathology Bldg., Box M045, 1335 E. Catherine Street, The University of Michigan Medical School, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Tokyo Municipal Okubo Hospital, Division of ENT, Kabukicho 2–44–1, Shinjukuku, Tokyo, Japan ; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Pathology, Medical College of Ohio, Toledo, Ohio; and the Department of Medicine, Division of Rheumatology, University of Connecticut, Farmington, Connecticut. | en_US |
dc.contributor.affiliationum | Department of Pathology, MedicalCollege of Ohio ; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Pathology, Medical College of Ohio, Toledo, Ohio; and the Department of Medicine, Division of Rheumatology, University of Connecticut, Farmington, Connecticut. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School ; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Pathology, Medical College of Ohio, Toledo, Ohio; and the Department of Medicine, Division of Rheumatology, University of Connecticut, Farmington, Connecticut. | en_US |
dc.contributor.affiliationum | Rheumatology Section, Hospital of the University of Pennsylvania, Philadelphia. ; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Pathology, Medical College of Ohio, Toledo, Ohio; and the Department of Medicine, Division of Rheumatology, University of Connecticut, Farmington, Connecticut. | en_US |
dc.identifier.pmid | 6458304 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37757/1/1780240906_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780240906 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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