A Murine Model of Polymyositis Induced by Coxsackievirus B1 (Tucson Strain)
dc.contributor.author | Strongwater, Steven L. | en_US |
dc.contributor.author | Dorovini-zis, Katerina | en_US |
dc.contributor.author | Ball, Richard D. | en_US |
dc.contributor.author | Schnitzer, Thomas J. | en_US |
dc.date.accessioned | 2006-04-28T16:23:33Z | |
dc.date.available | 2006-04-28T16:23:33Z | |
dc.date.issued | 1984-04 | en_US |
dc.identifier.citation | Strongwater, Steven L.; Dorovini-zis, Katerina; Ball, Richard D.; Schnitzer, Thomas J. (1984)."A Murine Model of Polymyositis Induced by Coxsackievirus B1 (Tucson Strain)." Arthritis & Rheumatism 27(4): 433-442. <http://hdl.handle.net/2027.42/37767> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37767 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6324823&dopt=citation | en_US |
dc.description.abstract | A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVB T ) is described. Intraperitoneal CVB T inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVB T -infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection. | en_US |
dc.format.extent | 966856 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | A Murine Model of Polymyositis Induced by Coxsackievirus B1 (Tucson Strain) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Ann Arbor, Michigan. ; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 6324823 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37767/1/1780270411_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780270411 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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