Connective tissue activation
dc.contributor.author | Gordon, Michael A. | en_US |
dc.contributor.author | Hollenberg, Morley D. | en_US |
dc.contributor.author | Castor, C. William | en_US |
dc.date.accessioned | 2006-04-28T16:23:40Z | |
dc.date.available | 2006-04-28T16:23:40Z | |
dc.date.issued | 1984-07 | en_US |
dc.identifier.citation | Gordon, Michael A.; Hollenberg, Morley D.; Castor, C. William (1984)."Connective tissue activation." Arthritis & Rheumatism 27(7): 780-788. <http://hdl.handle.net/2027.42/37769> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37769 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6611161&dopt=citation | en_US |
dc.description.abstract | A protein factor in human urine which has the ability to activate connective tissue cells has been identified and partially purified; it appears to be different from epidermal growth factor and IgG. This urinary connective tissue activating factor (CTAP-U) is nondialyzable, labile to protease, stable to thiols, heat, and acid, and has an acidic isoelectric point. Purified preparations of CTAP-U have biologic activities that cause human connective tissue cells to synthesize incremental amounts of 14 C-hyaluronic acid, 35 S-proteoglycans, and 3 H-DNA in vitro. The cell spectrum responsive to this substance includes human synovial cells, human chondrocytes, and skin fibroblasts. CTAP-U does not react with antisera to connective tissue activating peptide-III or to antibodies against IgG or its Fc and Fab fragments. Furthermore, CTAP-U does not cross-react in a radioreceptor assay for insulin, basic somatomedin, or epidermal growth factor-urogastrone. Utilizing standardized isolation conditions, CTAP-U preparations with these properties have been isolated from the urine of 6 normal individuals. | en_US |
dc.format.extent | 754105 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Connective tissue activation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor and the Department of Pharmacology and Experimental Therapeutics, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. | en_US |
dc.contributor.affiliationum | Department of Pharmacology and Experimental Therapeutics, University of Calgary Faculty of Medicine ; Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor and the Department of Pharmacology and Experimental Therapeutics, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor and the Department of Pharmacology and Experimental Therapeutics, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. ; Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 6611161 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37769/1/1780270709_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780270709 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.