Experimental osteoarthritis induced by selective myectomy and tendotomy
dc.contributor.author | Arsever, Christiane L. | en_US |
dc.contributor.author | Bole, Giles G. | en_US |
dc.date.accessioned | 2006-04-28T16:23:55Z | |
dc.date.available | 2006-04-28T16:23:55Z | |
dc.date.issued | 1986-02 | en_US |
dc.identifier.citation | Arsever, Christiane L.; Bole, Giles G. (1986)."Experimental osteoarthritis induced by selective myectomy and tendotomy." Arthritis & Rheumatism 29(2): 251-261. <http://hdl.handle.net/2027.42/37774> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37774 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3954807&dopt=citation | en_US |
dc.description.abstract | A new model of osteoarthritis has been developed that utilizes an extraarticular surgical technique to alter gait and weight-bearing capabilities in the hind limbs of experimental animals. Guinea pigs, averaging 650 gm in weight, were subjected to unilateral resection of a segment of the gluteal muscles at the sacral origin, to section of the infrapatellar ligament, or to both procedures. Progressive changes consistent with osteoarthritis developed over 10–24 weeks as judged by gross, radiologic, and microscopic findings. In addition, an increase in mean cartilage water content and 35 SO 4 −2 incorporation into proteoglycans by 10 and 14 weeks, respectively, were consistent with the chemical changes observed in early osteoarthritis. Abnormalities developed not only in the operated hind limb, but in the contralateral, unoperated hind limb at a slightly later time. Thus, this animal model provided the opportunity to evaluate a mild gait abnormality and other biomechanical influences on the evolution of osteoarthritis which is uninfluenced by any intraarticular joint trauma. | en_US |
dc.format.extent | 1110620 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Experimental osteoarthritis induced by selective myectomy and tendotomy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Rheumatology, Rackham Arthritis Research Unit, the University of Michigan Medical Center, Ann Arbor, Michigan 48109-0010 | en_US |
dc.contributor.affiliationum | Division of Rheumatology, Rackham Arthritis Research Unit, the University of Michigan Medical Center, Ann Arbor, Michigan 48109-0010 ; University of Michigan Medical Center, Department of Internal Medicine, Division of Rheumatology, Rackham Arthritis Research Unit, Box 018, Ann Arbor, MI 48109-0010 | en_US |
dc.identifier.pmid | 3954807 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37774/1/1780290214_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780290214 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.