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Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

dc.contributor.authorRichardson, Bruce C.en_US
dc.contributor.authorScheinbart, Leeen_US
dc.contributor.authorStrahler, John R.en_US
dc.contributor.authorGross, Laura A.en_US
dc.contributor.authorHanash, Samir M.en_US
dc.contributor.authorJohnson, Marcia A.en_US
dc.date.accessioned2006-04-28T16:24:22Z
dc.date.available2006-04-28T16:24:22Z
dc.date.issued1990-11en_US
dc.identifier.citationRichardson, Bruce; Scheinbart, Lee; Strahler, John; Gross, Laura; Hanash, Samir; Johnson, Marcia (1990)."Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis." Arthritis & Rheumatism 33(11): 1665-1673. <http://hdl.handle.net/2027.42/37783>en_US
dc.identifier.issn0004-3591en_US
dc.identifier.issn1529-0131en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/37783
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2242063&dopt=citationen_US
dc.description.abstractProcainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.en_US
dc.format.extent922287 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherRheumatologyen_US
dc.titleEvidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, and Veterans Administration Hospital ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan. ; Department of Internal Medicine. University of Michigan. Ann Arbor, MI 48109en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan ; Departments of Internal Medicine and Pediatrics, University of Michigan, and the Veterans Administration Hospital, Ann Arbor, Michigan.en_US
dc.identifier.pmid2242063en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/37783/1/1780331109_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/art.1780331109en_US
dc.identifier.sourceArthritis & Rheumatismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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