Phenotypic and functional similarities between 5-azacytidine-treated t cells and a t cell subset in patients with active systemic lupus erythematosus
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.contributor.author | Strahler, John R. | en_US |
dc.contributor.author | Pivirotto, T. Scott | en_US |
dc.contributor.author | Quddus, Jawaid | en_US |
dc.contributor.author | Bayliss, Garry E. | en_US |
dc.contributor.author | Gross, Laura A. | en_US |
dc.contributor.author | O'Rourke, Kenneth S. | en_US |
dc.contributor.author | Powers, Daniel | en_US |
dc.contributor.author | Hanash, Samir M. | en_US |
dc.contributor.author | Johnson, Marcia A. | en_US |
dc.date.accessioned | 2006-04-28T16:24:48Z | |
dc.date.available | 2006-04-28T16:24:48Z | |
dc.date.issued | 1992-06 | en_US |
dc.identifier.citation | Richardson, Bruce C.; Strahler, John R.; Pivirotto, T. Scott; Quddus, Jawaid; Bayliss, Garry E.; Gross, Laura A.; O'Rourke, Kenneth S.; Powers, Daniel; Hanash, Samir M.; Johnson, Marcia A. (1992)."Phenotypic and functional similarities between 5-azacytidine-treated t cells and a t cell subset in patients with active systemic lupus erythematosus." Arthritis & Rheumatism 35(6): 647-662. <http://hdl.handle.net/2027.42/37792> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37792 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1376122&dopt=citation | en_US |
dc.description.abstract | Objective. Antigen-specific CD4+ T cells treated with DNA methylation inhibitors become autoreactive, suggesting a novel mechanism for autoimmunity. To test whether this mechanism might be involved in systemic lupus erythematosus (SLE), phenotypic markers for the autoreactive cells were sought. Methods. Cloned normal T cells were treated with the DNA methylation inhibitor 5-azacytidine (5-azaC) and studied for altered gene expression. T cells from patients with active SLE were then studied for a similar change in gene expression, and cells expressing the marker were tested for autoreactivity. Results. 5-azaC-treated normal T cells had increased CD11a (leukocyte function-associated antigen 1Α) expression relative to other membrane molecules. A T cell subset with similar CD11a expression was found in patients with active SLE. This subset contained cells that spontaneously lysed autologous macrophages, with a specificity similar to that of 5-azaC-treated cells. Conclusion. The model of 5-azaC-induced autoreactivity may have relevance to SLE. | en_US |
dc.format.extent | 1549895 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Phenotypic and functional similarities between 5-azacytidine-treated t cells and a t cell subset in patients with active systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. ; 4550 Kresge 1, Box 0531, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.contributor.affiliationum | Internal Medicine, Pediatrics, and Human Genetics, University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. | en_US |
dc.identifier.pmid | 1376122 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37792/1/1780350608_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780350608 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.