Mechanisms of drug-induced lupus. III. Sex-specific differences in T cell homing may explain increased disease severity in female mice
dc.contributor.author | Yung, Raymond L. | en_US |
dc.contributor.author | Williams, Robert | en_US |
dc.contributor.author | Johnson, Kent J. | en_US |
dc.contributor.author | Phillips, Carrie | en_US |
dc.contributor.author | Stoolman, Lloyd M. | en_US |
dc.contributor.author | Chang, Sandra | en_US |
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.date.accessioned | 2006-04-28T16:25:50Z | |
dc.date.available | 2006-04-28T16:25:50Z | |
dc.date.issued | 1997-07 | en_US |
dc.identifier.citation | Yung, Raymond; Williams, Robert; Johnson, Kent; Phillips, Carrie; Stoolman, Lloyd; Chang, Sandra; Richardson, Bruce (1997)."Mechanisms of drug-induced lupus. III. Sex-specific differences in T cell homing may explain increased disease severity in female mice." Arthritis & Rheumatism 40(7): 1334-1343. <http://hdl.handle.net/2027.42/37813> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37813 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9214435&dopt=citation | en_US |
dc.description.abstract | Objective . To determine if sex-specific differences in lymphocyte trafficking could contribute to increased disease severity in female mice. Methods . A lupus-like disease was induced by injecting male and female mice with procainamide-treated T cell clones. Trafficking was examined by labeling the injected cells with 51 Cr or 5-chloromethylfluorescein diacetate. Results . Females developed more autoimmune liver disease and greater titers of anti-DNA antibodies than did males, and 2-7 times more cells accumulated in the female spleens. Splenectomy prevented the development of autoantibodies and renal and liver disease. Oophorectomy decreased the splenic homing, autoantibody titer, and liver disease severity, to levels found in males. Conclusion . T cells traffic differently to the spleen in male and female mice, and the spleen appears to be essential in the disease process. This suggests that differences in T cell homing could contribute to sex-specific disease severity in this murine model, and also possibly in human disease. | en_US |
dc.format.extent | 1057741 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Mechanisms of drug-induced lupus. III. Sex-specific differences in T cell homing may explain increased disease severity in female mice | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan ; R4540 Kresge 1, Box 0531, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 9214435 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37813/1/1780400719_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780400719 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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