Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo
dc.contributor.author | Yung, Raymond L. | en_US |
dc.contributor.author | Chang, Sandra | en_US |
dc.contributor.author | Hemati, Nahid | en_US |
dc.contributor.author | Johnson, Kent J. | en_US |
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.date.accessioned | 2006-04-28T16:25:53Z | |
dc.date.available | 2006-04-28T16:25:53Z | |
dc.date.issued | 1997-08 | en_US |
dc.identifier.citation | Yung, Raymond; Chang, Sandra; Hemati, Nahid; Johnson, Kent; Richardson, Bruce (1997)."Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo." Arthritis & Rheumatism 40(8): 1436-1443. <http://hdl.handle.net/2027.42/37814> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37814 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9259423&dopt=citation | en_US |
dc.description.abstract | Objective . T cells treated with DNA methylation inhibitors overexpress lymphocyte function-associated antigen 1 (LFA-1), which results in autoreactivity, and the autoreactive cells cause a lupus-like disease in vivo, suggesting a mechanism by which some agents may cause drug-induced lupus. This study compared the effects of procainamide (Pca) and hydralazine (Hyd) with those of structural analogs, to determine if the degree of LFA-1 overexpression and T cell autoreactivity correlated with the ability of the agents to induce autoimmunity. Methods . Cloned murine T helper 2 cells were treated with Pca, N -acetylprocainamide, Hyd, Phthalazine, or hydroxyurea (HU). The treated cells were then compared for LFA-1 overexpression, autoreactivity, and the ability to induce autoimmunity in vivo. Results . Pca and Hyd were more potent than their analogs or HU in all 3 assays. Conclusion . The results support a relationship between LFA-1 overexpression, T cell autoreactivity, and autoimmunity, and suggest a mechanism by which Pca and Hyd, but not the analogs, may cause drug-induced lupus. | en_US |
dc.format.extent | 744535 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan ; R4540 Kresge 1, Ann Arbor, MI 48109-0531 | en_US |
dc.identifier.pmid | 9259423 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37814/1/1780400811_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780400811 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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