Equilibrium swelling of pigment gallstones: Evidence for network polymer structure
dc.contributor.author | Black, Brian E. | en_US |
dc.contributor.author | Carr, Stephen H. | en_US |
dc.contributor.author | Ohkubo, Hideki | en_US |
dc.contributor.author | Ostrow, J. Donald | en_US |
dc.date.accessioned | 2006-04-28T16:27:21Z | |
dc.date.available | 2006-04-28T16:27:21Z | |
dc.date.issued | 1982-03 | en_US |
dc.identifier.citation | Black, Brian E.; Carr, Stephen H.; Ohkubo, Hideki; Ostrow, J. Donald (1982)."Equilibrium swelling of pigment gallstones: Evidence for network polymer structure." Biopolymers 21(3): 601-610. <http://hdl.handle.net/2027.42/37844> | en_US |
dc.identifier.issn | 0006-3525 | en_US |
dc.identifier.issn | 1097-0282 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37844 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7066474&dopt=citation | en_US |
dc.description.abstract | A major component of pigment gallstones (PS) is a black, insoluble substance. It has been suggested that this pigment material might be a highly crosslinked polymer, and if such were the case, it should imbibe solvent (swell) to the maximum permitted by the crosslinks of its macromolecular network. We measured the equilibrium amount, q eq , by which pulverized, desiccated PS swells in different liquids, including isotonic aqueous buffers at pH values from 1.5–11.5. For ionic strengths ≥ 0.15, the dependence of q eq on pH exhibits a broad titration curve with a midpoint near pH 7. q eq was < 1.2 in methanol, dimethylformamide, dimethylsulfoxide, and chloroform. The ir absorbance from vinyl groups in the black pigment was only one-eighth that of unconjugated bilirubin, the primary chemical building block of PS; this implicates vinyl groups in the formation of a polymer network. The rise in q eq with increasing pH suggests that the carboxyl groups are free to ionize and are therefore not involved in the covalent bonds that make the crosslinked polymer. A network polymer structure would account for the inability to dissolve PS in those solvents in which unconjugated bilirubin is soluble. | en_US |
dc.format.extent | 538193 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Equilibrium swelling of pigment gallstones: Evidence for network polymer structure | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan 48104 | en_US |
dc.contributor.affiliationother | Department of Materials Science and Engineering and Materials Research Center, Northwestern University, Evanston, Illinois 60201 ; Department of Materials Science and Engineering and Materials Research Center, Northwestern University, Evanston, Illinois 60201 | en_US |
dc.contributor.affiliationother | Department of Medicine, Northwestern University and Veterans Administration Lakeside Medical Center, Chicago, Illinois 60611 | en_US |
dc.contributor.affiliationother | Department of Medicine, Northwestern University and Veterans Administration Lakeside Medical Center, Chicago, Illinois 60611 | en_US |
dc.identifier.pmid | 7066474 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37844/1/360210309_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bip.360210309 | en_US |
dc.identifier.source | Biopolymers | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.