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The effects of idiotype on the ability of IgG 1 antiphosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae
dc.contributor.authorBriles, David E.en_US
dc.contributor.authorForman, Colynnen_US
dc.contributor.authorHudak, Susanen_US
dc.contributor.authorClaflin, J. Lathamen_US
dc.date.accessioned2006-04-28T16:33:06Z
dc.date.available2006-04-28T16:33:06Z
dc.date.issued1984en_US
dc.identifier.citationBriles, David E.; Forman, Colynn; Hudak, Susan; Claflin, J. Latham (1984)."The effects of idiotype on the ability of IgG 1 antiphosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae ." European Journal of Immunology 14(11): 1027-1030. <http://hdl.handle.net/2027.42/37959>en_US
dc.identifier.issn0014-2980en_US
dc.identifier.issn1521-4141en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/37959
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6333985&dopt=citationen_US
dc.description.abstractAnti-phosphorylcholine (PC) antibodies of the mouse are found in three different idiotype families: T15, M603 and M511. These subgroups exhibit different specificities for PC analogs and utilize light chains of different V L subgroups. In this study we have found that IgG 1 antibodies of the T15 idiotype are much more protective against pneumococcal infection than IgG 1 antibodies of the M511 or M603 idiotypes. This finding provides additional evidence that the T15 V H and V L genes may have evolved to protect mice from infection with PC-bearing pathogens.en_US
dc.format.extent457227 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWILEY-VCH Verlag GmbHen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherMicrobiology and Immunologyen_US
dc.titleThe effects of idiotype on the ability of IgG 1 antiphosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniaeen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumThe Cellular Immunobiology Unit of the Tumor Institute, University of Michigan Medical School, Michigan ; Recipient of a Research Career Development Award, AI 00498. ; 224 Tumor Institute, University of Alabama in Birmingham, University Station, Birmingham, Alabama, AL 35294, USAen_US
dc.contributor.affiliationumThe Cellular Immunobiology Unit of the Tumor Institute, University of Michigan Medical School, Michiganen_US
dc.contributor.affiliationumDepartment of Microbiology and The Comphrehensive Cancer Center, University of Alabama in Birmingham and Departments of Microbiology and Immunology, University of Michigan Medical School, Michiganen_US
dc.contributor.affiliationumDepartment of Microbiology and The Comphrehensive Cancer Center, University of Alabama in Birmingham and Departments of Microbiology and Immunology, University of Michigan Medical School, Michiganen_US
dc.identifier.pmid6333985en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/37959/1/1830141112_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/(ISSN)1521-4141en_US
dc.identifier.sourceEuropean Journal of Immunologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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