Calcification of valved aortic allografts in rats: Effects of age, crosslinking, and inhibitors
dc.contributor.author | Levy, Robert J. | en_US |
dc.contributor.author | Qu, Xuan | en_US |
dc.contributor.author | Underwood, Thomas | en_US |
dc.contributor.author | Trachy, Joseph | en_US |
dc.contributor.author | Schoen, Frederick J. | en_US |
dc.date.accessioned | 2006-04-28T16:35:40Z | |
dc.date.available | 2006-04-28T16:35:40Z | |
dc.date.issued | 1995-02 | en_US |
dc.identifier.citation | Levy, Robert J.; Qu, Xuan; Underwood, Thomas; Trachy, Joseph; Schoen, Frederick J. (1995)."Calcification of valved aortic allografts in rats: Effects of age, crosslinking, and inhibitors." Journal of Biomedical Materials Research 29(2): 217-226. <http://hdl.handle.net/2027.42/38009> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38009 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7738069&dopt=citation | en_US |
dc.description.abstract | Experiments were carried out to investigate rat aortic allograft calcification using valved abdominal aortic allografts. Results indicated that this was a potentially useful model for investigating fresh allograft calcification, as well as mineralization of glutaraldehyde-crosslinked valved allografts. Valve cusp results, however, were not comparable to those noted in large animal or human studies, while aortic wall calcification was more comparable. Calcification inhibitor investigations demonstrated that nearly complete inhibition of the calcification of the aortic wall of glutaraldehyde-crosslinked allografts was achieved using a number of individual inhibitors, including controlled release diphosphonates, and pretreatment with either ferric chloride or aluminum chloride. However, aminopropanehydroxydiphosphonate pretreatment was not efficacious, and sodium dodecyl sulfate pretreatment was only partially effective for inhibiting the aortic wall calcification in the glutaraldehyde-crosslinked allografts. It is concluded that valved aortic allografts in rats provide a useful model for investigating aortic wall (but not valve cusp) calcification and its inhibition. © 1995 John Wiley & Sons, Inc. | en_US |
dc.format.extent | 1189291 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Calcification of valved aortic allografts in rats: Effects of age, crosslinking, and inhibitors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan ; University of Michigan, Department of Pediatrics, R5014 Kresge II 0576 Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Brigham and Women's Hospital, Boston, Massachusetts | en_US |
dc.identifier.pmid | 7738069 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38009/1/820290212_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.820290212 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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