Development and characterization of a biodegradable polyphosphate
dc.contributor.author | Renier, Michael L. | en_US |
dc.contributor.author | Kohn, David H. | en_US |
dc.date.accessioned | 2006-04-28T16:35:51Z | |
dc.date.available | 2006-04-28T16:35:51Z | |
dc.date.issued | 1997-01 | en_US |
dc.identifier.citation | Renier, Michael L.; Kohn, David H. (1997)."Development and characterization of a biodegradable polyphosphate." Journal of Biomedical Materials Research 34(1): 95-104. <http://hdl.handle.net/2027.42/38013> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38013 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8978658&dopt=citation | en_US |
dc.description.abstract | A biodegradable polyphosphate polymer (M n = 18,000, M w /M n = 3.2) matrix system was developed as a potential delivery vehicle for growth factors. As a model system, release of recombinant human osteogenic protein-1 (OP-1) from this polymer was evaluated. The polyphosphate was synthesized using a triethylamine catalyst in an argon environment, and characterized using elemental analysis, gel permeation chromatography (GPC), and Fourier transform infrared spectroscopy (FTIR). Degradation kinetics of the polyphosphate polymer in phosphate-buffered saline (PBS) were represented by a second-order polynomial while degradation in bovine serum was linear with time. The polymer degraded faster in PBS than in bovine serum. In vitro release of OP-1 was also faster in PBS than in serum. Release kinetics of OP-1 in PBS and serum were represented by second-order polynomials. The OP-1 release from this physically dispersed polymeric matrix may be described by several possible mechanisms: diffusion, bulk polymer degradation, ion complexation, and interactions among the protein (OP-1), polymer, proteins, and enzymes in the media. This polyphosphate may be an effective carrier for morphogens, growth factors, or other classes of bioactive molecules. © 1997 John Wiley & Sons, Inc. | en_US |
dc.format.extent | 342778 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Development and characterization of a biodegradable polyphosphate | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078 ; College of Pharmacy, and Bioengineering Program, University of Michigan, Ann Arbor, MI 48109-1078 | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078 ; College of Pharmacy, and Bioengineering Program, University of Michigan, Ann Arbor, MI 48109-1078 ; Department of Biologic and Materials Sciences, School of Dentistry, and Bioengineering Program, University of Michigan, Ann Arbor, MI 48109-1078 | en_US |
dc.identifier.pmid | 8978658 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38013/1/13_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1097-4636(199701)34:1<95::AID-JBM13>3.0.CO;2-O | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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