Fetal and placental responses to artificially induced hyperthermia in rats
dc.contributor.author | Arora, K. L. | en_US |
dc.contributor.author | Cohen, Bennett J. | en_US |
dc.contributor.author | Beaudoin, Allan R. | en_US |
dc.date.accessioned | 2006-04-28T16:41:55Z | |
dc.date.available | 2006-04-28T16:41:55Z | |
dc.date.issued | 1979-04 | en_US |
dc.identifier.citation | Arora, K. L.; Cohen, B. J.; Beaudoin, A. R. (1979)."Fetal and placental responses to artificially induced hyperthermia in rats." Teratology 19(2): 251-259. <http://hdl.handle.net/2027.42/38132> | en_US |
dc.identifier.issn | 0040-3709 | en_US |
dc.identifier.issn | 1096-9926 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38132 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=473076&dopt=citation | en_US |
dc.description.abstract | Pregnant rats were utilized to study the effect of maternal hyperthermia on fetal development. Eight groups of six to eight rats were exposed to ambient temperatures of 43-44cC at various stages of pregnancy. All rats were killed on day 20 of gestation. Edema, microencephaly and microph-thalmia followed heat treatment on day 4, 6, or 8 and skeletal defects occurred on day 10 of gestation. Apparently heat stress of dams after day 14 of gestation had little or no effect on embryos. Most placentas from day 6-10 treatment groups were significantly heavier than control and exhibited extensive thickening and necrosis of decidua basalis. Our results suggest that the rat is a useful model for investigating maternal hyperthermia as a possible cause of human placentophathies and fetal retardation. | en_US |
dc.format.extent | 3022352 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Fetal and placental responses to artificially induced hyperthermia in rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Unit for Laboratory Animal Medicine and Department of Anatomy, University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Unit for Laboratory Animal Medicine and Department of Anatomy, University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Unit for Laboratory Animal Medicine and Department of Anatomy, University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 473076 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38132/1/1420190216_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/tera.1420190216 | en_US |
dc.identifier.source | Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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