Genetic aspects of the effects of methylmercury in mice: The incidence of cleft palate and concentrations of adenosine 3′:5′ cyclic monophosphate in tongue and palatal shelf
dc.contributor.author | Harper, Kenneth J. | en_US |
dc.contributor.author | Burns, Risa | en_US |
dc.contributor.author | Erickson, Robert P. | en_US |
dc.date.accessioned | 2006-04-28T16:42:40Z | |
dc.date.available | 2006-04-28T16:42:40Z | |
dc.date.issued | 1981-06 | en_US |
dc.identifier.citation | Harper, Kenneth; Burns, Risa; Erickson, Robert P. (1981)."Genetic aspects of the effects of methylmercury in mice: The incidence of cleft palate and concentrations of adenosine 3′:5′ cyclic monophosphate in tongue and palatal shelf." Teratology 23(3): 397-401. <http://hdl.handle.net/2027.42/38148> | en_US |
dc.identifier.issn | 0040-3709 | en_US |
dc.identifier.issn | 1096-9926 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38148 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6266065&dopt=citation | en_US |
dc.description.abstract | Concentrations of adenosine 3′:5′ cyclic monophosphate (cAMP) were measured in the tongues and palates of 14.5-day-old fetuses from control and methylmercury-treated mothers of four inbred lines of mice which represent the four possible combinations of two H-2 alleles and two residual genetic backgrounds. The incidence of cleft palate in fetuses from control and methylmercury-treated mothers was also examined. The H-2 alleles significantly affected the degree of reduction of cAMP concentration in palates seen in fetuses from mothers treated with methylmercury. Neither the H-2 allele nor the residual genetic background played a role in the effect of methylmercury on cAMP concentrations in fetal tongues. The magnitude of increase in the incidence of cleft palate with methylmercury treatment was approximately the same for all lines. Thus, methylmercury-induced cleft palate may not be mediated by the reduction of cAMP. Finally, fetuses with cleft lip had increased palatal cAMP levels, whether or not they were from control or methylmercury treated mothers. | en_US |
dc.format.extent | 364010 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Genetic aspects of the effects of methylmercury in mice: The incidence of cleft palate and concentrations of adenosine 3′:5′ cyclic monophosphate in tongue and palatal shelf | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics and Pediatrics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Human Genetics and Pediatrics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Human Genetics and Pediatrics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 6266065 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38148/1/1420230315_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/tera.1420230315 | en_US |
dc.identifier.source | Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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