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An exploration of the role of hydroxyurea injection time in fetal growth and teratogenesis in rats
dc.contributor.authorBarr, Masonen_US
dc.contributor.authorBeaudoin, Allan R.en_US
dc.date.accessioned2006-04-28T16:42:49Z
dc.date.available2006-04-28T16:42:49Z
dc.date.issued1981-10en_US
dc.identifier.citationBarr, Mason; Beaudoin, Allan R. (1981)."An exploration of the role of hydroxyurea injection time in fetal growth and teratogenesis in rats." Teratology 24(2): 163-167. <http://hdl.handle.net/2027.42/38151>en_US
dc.identifier.issn0040-3709en_US
dc.identifier.issn1096-9926en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/38151
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7336359&dopt=citationen_US
dc.description.abstractPregnant Wistar rats were injected with hydroxyurea (HU) intraperitoneally (IP) at one of several 6-hour intervals on days 9–10.75 to study the role of circadian growth variations in the teratologic response of the fetuses. Two stocks of rats were studied and the results in each compared. The fetal response to HU, as observed at day 21, was not detectably modified by circadian fetal growth variation. No correlations between hour of HU administration and fetal weight, placental weight, resorption, or total malformation rates were found. Cyclic variations in the incidence of hydronephrosis and left umbilical artery was observed, but it was not clear that these were related to maternal light:dark cycles. Differences of response between two stocks of rats included marked variation in the incidence and type of malformations and variations in the tuning of peak incidence for some but not all malformations.en_US
dc.format.extent432797 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleAn exploration of the role of hydroxyurea injection time in fetal growth and teratogenesis in ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics and Anatomy, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Pediatrics and Anatomy, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid7336359en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/38151/1/1420240207_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/tera.1420240207en_US
dc.identifier.sourceTeratologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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