Comparison of a low osmolarity nonionic radiographic contrast agent with a standard medium on renal function in cyanotic and normal dogs
dc.contributor.author | Pridjian, Ara K. | en_US |
dc.contributor.author | Bove, Edward L. | en_US |
dc.contributor.author | Beekman III, Robert H. | en_US |
dc.contributor.author | Lupinetti, Flavian M. | en_US |
dc.date.accessioned | 2006-04-28T16:46:34Z | |
dc.date.available | 2006-04-28T16:46:34Z | |
dc.date.issued | 1994-01 | en_US |
dc.identifier.citation | Pridjian, Ara K.; Bove, Edward L.; Beekman, Robert H.; Lupinetti, Flavian M. (1994)."Comparison of a low osmolarity nonionic radiographic contrast agent with a standard medium on renal function in cyanotic and normal dogs." Catheterization and Cardiovascular Diagnosis 31(1): 90-93. <http://hdl.handle.net/2027.42/38218> | en_US |
dc.identifier.issn | 0098-6569 | en_US |
dc.identifier.issn | 1097-0304 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38218 | |
dc.description.abstract | Renal dysfunction may follow administration of iodinated radiographic contrast agents. This complication may be less common when low osmolarity nonionic agents are used. Although potential benefits from the use of low osmolarity nonionic contrast may be minimal in individuals with normal physiology, a greater benefit has been postulated in the presence of chronic cyanosis. To test this hypothesis, six adult mongrel dogs underwent anastomosis of the inferior vena cava to the left atrium. This produced chronic cyanosis with a mean pO 2 of 48 ± 4 mm Hg and polycythemia with a mean hematocrit of 56 ± 2 gm%. Three to 5 months after preparation, these cyanotic dogs and five control dogs each received diatrizoate (a high osmolarity ionic agent) or ioversol (a low osmolarity nonionic agent), 465 mg iodine/kg body weight, by intravenous bolus injection. One month later, each animal received the other agent. The order of administration was randomized. Renal function studies, including serum creatinine and creatinine clearance, were performed precontrast, after 60 min, and 24 hr postcontrast. Neither agent adversely affected renal function in either the cyanotic or the normal group. We conclude that at the doses that are commonly used in clinical practice, high osmolarity ionic contrast agents do not create a greater risk of renal injuiry than do low osmolarity nonionic agents in this model of cyanosis. | en_US |
dc.format.extent | 396898 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cardiovascular Medicine | en_US |
dc.title | Comparison of a low osmolarity nonionic radiographic contrast agent with a standard medium on renal function in cyanotic and normal dogs | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatric Cardiolgy and Surgery, Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor | en_US |
dc.contributor.affiliationum | Departments of Pediatric Cardiolgy and Surgery, Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor | en_US |
dc.contributor.affiliationum | Departments of Pediatric Cardiolgy and Surgery, Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor | en_US |
dc.contributor.affiliationum | Departments of Pediatric Cardiolgy and Surgery, Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor | en_US |
dc.identifier.pmid | 8118866 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38218/1/1810310118_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ccd.1810310118 | en_US |
dc.identifier.source | Catheterization and Cardiovascular Diagnosis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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