Lesion-directed administration of alteplase with intracoronary heparin in patients with unstable angina and coronary thrombus undergoing angioplasty
dc.contributor.author | Gurbel, Paul A. | en_US |
dc.contributor.author | Navetta, Frank I. | en_US |
dc.contributor.author | Bates, Eric R. | en_US |
dc.contributor.author | Muller, David W. M. | en_US |
dc.contributor.author | Tenaglia, Alan N. | en_US |
dc.contributor.author | Miller, Michael J. | en_US |
dc.contributor.author | Muhlstein, Brent | en_US |
dc.contributor.author | Hermillerxyj, James B. | en_US |
dc.contributor.author | Davidson, Charles J. | en_US |
dc.contributor.author | Aguirre, Frank V. | en_US |
dc.contributor.author | Beauman, Glenn J. | en_US |
dc.contributor.author | Berdan, Lisa G. | en_US |
dc.contributor.author | Leimberger, Jeffrey D. | en_US |
dc.contributor.author | Bovill, Edwin G. | en_US |
dc.contributor.author | Christenson, Robert H. | en_US |
dc.contributor.author | Ohman, E. Magnus | en_US |
dc.date.accessioned | 2006-04-28T16:46:46Z | |
dc.date.available | 2006-04-28T16:46:46Z | |
dc.date.issued | 1996-04 | en_US |
dc.identifier.citation | Gurbel, Paul A.; Navetta, Frank I.; Bates, Eric R.; Muller, David W.; Tenaglia, Alan N.; Miller, Michael J.; Muhlstein, Brent; Hermillerxyj, James B.; Davidson, Charles J.; Aguirre, Frank V.; Beauman, Glenn J.; Berdan, Lisa G.; Leimberger, Jeffrey D.; Bovill, Edwin G.; Christenson, Robert H.; Ohman, E. Magnus (1996)."Lesion-directed administration of alteplase with intracoronary heparin in patients with unstable angina and coronary thrombus undergoing angioplasty." Catheterization and Cardiovascular Diagnosis 37(4): 382-391. <http://hdl.handle.net/2027.42/38222> | en_US |
dc.identifier.issn | 0098-6569 | en_US |
dc.identifier.issn | 1097-0304 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38222 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8721695&dopt=citation | en_US |
dc.description.abstract | Percutaneous coronary revascularization in patients with unstable angina and coronary thrombus carries a high complication rate. A new strategy to reduce thrombus burden before revascularization was tested in a multicenter prospective trial. Patients with unstable angina and coronary thrombus (n = 45) received alteplase through an infusion catheter at the proximal aspect of the target lesion and concomitant intracoronary heparin via a standard guiding catheter. Angiography was performed before and after lesiondirected therapy and post-intervention. Systemic fibrinogen depletion and thrombin activation were not observed, while fibrinolysis was evident for ≥4 hr after treatment. Target lesion stenosis did not change significantly after lesion-directed therapy, but thrombus score was reduced, particularly among patients who had large thrombi (mean 2.2 vs. 1.6, P = 0.02). Revascularization was successful in 89% of patients. Median final stenosis was 30% and mean final thrombus score was 0.4. Complications included recurrent ischemia (11%), MI (7%), abrupt closure (7%), severe bleeding (4%), and repeat emergency angioplasty (2%). Patients with overt thrombus appeared to derive the most angiograpnic benefit from lesion-directed alteplase plus intracoronary heparin. Later revascularization was highly successful. This strategy may be a useful adjunct to percutaneous revascularization for patients with unstable angina and frank intracoronary thrombus. © 1996 Wiley-Liss, Inc. | en_US |
dc.format.extent | 957302 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cardiovascular Medicine | en_US |
dc.title | Lesion-directed administration of alteplase with intracoronary heparin in patients with unstable angina and coronary thrombus undergoing angioplasty | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Medicine, University of Maryland Medical System, Baltimore, Maryland; Mother Frances Hospital, Tyler, Texas; University of Michigan Medical Center, Ann Arbor, Michigan; Tulane University Medical Center, New Orleans, Louisiana; University of South Carolina Medical Center, Charleston, South Carolina; Latter-Day Saints Hospital, Salt Lake City, Utah; St. Vincent's Medical Center, Indianapolis, Indiana; Division of Cardiology, Northwestern University, Chicago, Illinois; St. Louis University Health Sciences Center, St. Louis, Missouri; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; University of Vermont Medical Center, Burlington, Vermont ; P.O. Box 3151, Duke University Medical Center, Durham, NC 27710 | en_US |
dc.identifier.pmid | 8721695 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38222/1/1810370409_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ccd.1810370409 | en_US |
dc.identifier.source | Catheterization and Cardiovascular Diagnosis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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