Studies in man with cold-recombinant influenza virus (h1n1) live vaccines
dc.contributor.author | Reeve, P. | en_US |
dc.contributor.author | Gerendas, Batia | en_US |
dc.contributor.author | Liehl, E. | en_US |
dc.contributor.author | Hofmann, H. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | Kunz, C. | |
dc.date.accessioned | 2006-04-28T16:47:10Z | |
dc.date.available | 2006-04-28T16:47:10Z | |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Reeve, P.; Gerendas, Batia; E. Liehl, A. Moritz; H. Hofmann, C.Kunz; Maassab, H. F. (1980)."Studies in man with cold-recombinant influenza virus (h1n1) live vaccines." Journal of Medical Virology 6(1): 75-83. <http://hdl.handle.net/2027.42/38229> | en_US |
dc.identifier.issn | 0146-6615 | en_US |
dc.identifier.issn | 1096-9071 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38229 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7014783&dopt=citation | en_US |
dc.description.abstract | Two cold-recombinant influenza A (H1N1) viruses were tested in several groups of human volunteers. Only minor clinical symptoms were seen and no febrile reactions occurred. With serologically primed individuals virus shedding was low, but a high proportion showed rises in serum antibody levels after vaccination and mean titres were high. With serologically unprimed volunteers shedding was high, about 75% yielding viruses but only at low titres and for a short duration. No revertant viruses were found and there was no evidence of transmission to potentially susceptible individuals housed in close contact to the vaccinees. Serum antibody responses with unprimed volunteers were, however, low. Only about one half showed increases in serum antibody titres after vaccination and mean titres were low. Nevertheless, challenge with live attenuated virus indicated a high degree of protection based on virological evidence of infection. | en_US |
dc.format.extent | 520034 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Studies in man with cold-recombinant influenza virus (h1n1) live vaccines | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | National Institute for Biological Standards, London (P.R.), Sandoz Research Institute, Vienna (B.C., A.M., E.L), Institut fÚr Virologie, UniversitÄt Wien (O.K., H.H.), and University of Michigan, Ann Arbor (H.F.M.) | en_US |
dc.contributor.affiliationum | National Institute for Biological Standards, London (P.R.), Sandoz Research Institute, Vienna (B.C., A.M., E.L), Institut fÚr Virologie, UniversitÄt Wien (O.K., H.H.), and University of Michigan, Ann Arbor (H.F.M.) | en_US |
dc.contributor.affiliationum | National Institute for Biological Standards, London (P.R.), Sandoz Research Institute, Vienna (B.C., A.M., E.L), Institut fÚr Virologie, UniversitÄt Wien (O.K., H.H.), and University of Michigan, Ann Arbor (H.F.M.) | en_US |
dc.contributor.affiliationum | National Institute for Biological Standards, London (P.R.), Sandoz Research Institute, Vienna (B.C., A.M., E.L), Institut fÚr Virologie, UniversitÄt Wien (O.K., H.H.), and University of Michigan, Ann Arbor (H.F.M.) | en_US |
dc.contributor.affiliationum | National Institute for Biological Standards, London (P.R.), Sandoz Research Institute, Vienna (B.C., A.M., E.L), Institut fÚr Virologie, UniversitÄt Wien (O.K., H.H.), and University of Michigan, Ann Arbor (H.F.M.) ; Address reprint requests to P. Reeve, National Institute for Biological Standards, Holly Hill, Hampstead, London NW3 6RB, England | en_US |
dc.identifier.pmid | 7014783 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38229/1/1890060110_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jmv.1890060110 | en_US |
dc.identifier.source | Journal of Medical Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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